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To identify additional genes contributing to allograft survival, a genome\u2010wide association study was performed in 532 AA DDs. Phenotypic data were obtained from the Scientific Registry of Transplant Recipients. Association and single\u2010nucleotide polymorphism (SNP)\u2010by\u2010<jats:italic>APOL1<\/jats:italic>interaction tests were conducted using death\u2010censored renal allograft survival accounting for relevant covariates. Replication and inverse\u2010variance\u2010weighted meta\u2010analysis were performed using data from 250 AA DD in the Genomics of Transplantation study. Accounting for<jats:italic>APOL1<\/jats:italic>, multiple SNPs near the Nudix Hydrolase 7 gene<jats:italic>(NUDT7)<\/jats:italic>showed strong independent effects (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.6\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>\u20102.2\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>). Several SNPs in the Translocation protein SEC63 homolog (<jats:italic>SEC63<\/jats:italic>;<jats:italic>P<\/jats:italic>\u00a0=\u00a02\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup>\u20103.7\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>) and plasmacytoma variant translocation 1 (<jats:italic>PVT1)<\/jats:italic>genes (<jats:italic>P<\/jats:italic>\u00a0=\u00a04.0\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>\u20107\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>) modified the effect of<jats:italic>APOL1<\/jats:italic>on allograft survival.<jats:italic>SEC63<\/jats:italic>is expressed in human renal tubule cells and glomeruli, and<jats:italic>PVT1<\/jats:italic>is associated with diabetic kidney disease. Overall, associations were detected for 41 SNPs (<jats:italic>P<\/jats:italic>\u00a0=\u00a02\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup>\u20105\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>) contributing independently or interacting with<jats:italic>APOL1<\/jats:italic>to impact renal allograft survival after transplantation from AA DD. Given the small sample size of the discovery and replication sets, independent validations and functional genomic efforts are needed to validate these results.<\/jats:p>","DOI":"10.1111\/ctr.13827","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T06:36:17Z","timestamp":1582266977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genome\u2010wide association study for time to failure of kidney transplants from African American deceased donors"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-7620","authenticated-orcid":false,"given":"Jasmin","family":"Divers","sequence":"first","affiliation":[{"name":"Division of Health Services Research Department of Foundations of Medicine NYU Long Island School of Medicine and NYU Winthrop Research Institute Mineola NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section on Nephrology Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Mark","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8883-2511","authenticated-orcid":false,"given":"Nicholette D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section on Nephrology Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-0430","authenticated-orcid":false,"given":"Ajay K.","family":"Israni","sequence":"additional","affiliation":[{"name":"Department of Medicine Hennepin Healthcare University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen O.","family":"Pastan","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University School of Medicine Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-1021","authenticated-orcid":false,"given":"Bruce A.","family":"Julian","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham School of Medicine Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Gaston","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham School of Medicine Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber M.","family":"Reeves\u2010Daniel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section on Nephrology Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-5530","authenticated-orcid":false,"given":"Barry I.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section on Nephrology Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.11.021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh022"},{"key":"e_1_2_8_4_1","volume-title":"USRDS 2015 Annual Data Report: End\u2010stage Renal Disease (ESRD) in the United States. 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