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Here, we explore the current status of ANLLD with special consideration of published reports; US experience; impact on donor psychosocial outcomes; barriers to donation; and current global trends with respect to ethical considerations. Between 1998 and 2019, 105 anonymous nondirected living liver donor (ND\u2010LLD) transplants have been documented in the US Scientific Registry of Transplant Recipients. Sixteen donors (15%) were reported to experience a postoperative complication. Currently, 89 donors remain alive (85%), 16 (15%) have unknown status, and none are confirmed deceased. Although there are only a handful of case series, these data suggest that ANLLD is a feasible option. While there are no liver\u2010specific data, studies involving anonymous nondirected kidney donors suggest that anonymous donation does not adversely impact psychosocial outcomes in donors or recipients. There are substantial financial burdens and ethical considerations related to ANLLD. Further studies are required to assess donor demographics, psychosocial motivations, long\u2010term health\u2010related quality of life, and financial impact of ANLLD.<\/jats:p>","DOI":"10.1111\/ctr.13836","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T10:49:23Z","timestamp":1583837363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Global experience and perspective on anonymous nondirected live donation in living donor liver transplantation"],"prefix":"10.1111","volume":"34","author":[{"given":"Muhammad H.","family":"Raza","sequence":"first","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Aziz","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Abdominal Transplant Surgery Department of Surgery University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Division of Hepatobiliary and Abdominal Transplant Surgery Department of Surgery University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Preventative Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Sher","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Division of Hepatobiliary and Abdominal Transplant Surgery Department of Surgery University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Genyk","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Division of Hepatobiliary and Abdominal Transplant Surgery Department of Surgery University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-3057","authenticated-orcid":false,"given":"Juliet","family":"Emamaullee","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles CA USA"},{"name":"Division of Hepatobiliary and Abdominal Transplant Surgery Department of Surgery University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15276"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.02.068"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.15"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.11.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.04.018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20227"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051517-125454"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.272.mor"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.015"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"133","article-title":"Living donor liver transplantation in the USA","volume":"5","author":"Kim PTW","year":"2016","journal-title":"Hepatobiliary Surg Nutr"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001383"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01725.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.01044.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03244.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.027"},{"key":"e_1_2_9_18_1","unstructured":"Extraordinary gift links two strangers for life after anonymous living donor transplant [Internet]. 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