{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:14:29Z","timestamp":1791688469430,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are little data on the pre\u2010 and post\u2013liver transplantation (LT) outcomes of patients having autoimmune hepatitis\u2010primary biliary cholangitis (AIH\u2010PBC), AIH\u2010primary sclerosing cholangitis (AIH\u2010PSC), and AIH\u2010small\u2010duct PSC (AIH\u2010SDPSC). The aim of this study was to analyze pre\u2010 and post\u2010LT outcomes and survival of patients having different overlap syndromes (OS) undergoing LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with compatible clinical and pathologic features of AIH\u2010PBC (n\u00a0=\u00a086), AIH\u2010PSC (n\u00a0=\u00a022), and AIH\u2010SDPSC (n\u00a0=\u00a09) were included in the study. Demographic, laboratory, clinical, and survival data were analyzed. Multivariable analyses were performed to determine factors predicting transplant\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AIH\u2010primary sclerosing cholangitis patients were less treatment\u2010responsive and were more likely to undergo LT than other OS. No survival difference was noted among the 3 groups. Liver decompensation was independently associated with higher mortality (HR 21.78; 95% CI 2.50\u2010190.01). Thirteen patients with OS underwent LT. One\u2010year survival post\u2010LT was 91.7%. Overall recurrence rate for OS post\u2010LT was 8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AIH\u2010primary sclerosing cholangitis patients were more likely to require LT compared with patients having AIH\u2010PBC. Transplant\u2010free survival was similar among the three AIH\u2010overlap syndromes. Allograft recurrence of OS occurred in about 10% of cases. Patients with OS appear to have good short\u2010 and medium\u2010term post\u2010LT outcomes in terms of graft function and overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13841","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T15:10:28Z","timestamp":1582125028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The clinical characteristics, pre\u2010 and post\u2013liver transplantation outcomes in patients having autoimmune overlap syndromes"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-5373","authenticated-orcid":false,"given":"Maneerat","family":"Chayanupatkul","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"Division of Liver Diseases Department of Medicine Icahn School of Medicine at Mount Sinai Recanati\u2010Miller Transplantation Institute New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Fiel","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Schiano","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases Department of Medicine Icahn School of Medicine at Mount Sinai Recanati\u2010Miller Transplantation Institute New York NY 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