{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:15:32Z","timestamp":1776269732946,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human leukocyte antigen (HLA)\u2010haploidentical hematopoietic stem cell transplantation (haplo\u2010HSCT) is an effective alternative to HLA\u2010matched transplantation. However, Epstein\u2010Barr virus (EBV) infection causes morbidity and mortality in patients undergoing haplo\u2010HSCT. Here, we retrospectively evaluated the incidence and risk factors of EBV\u2010DNAemia and EBV\u2010associated diseases in 131 patients who underwent haplo\u2010HSCT. Patients were classified into the no EBV infection groups, EBV\u2010DNAemia group and EBV\u2010associated disease group. Cumulative incidences of acute graft\u2010vs\u2010host disease, EBV infections, overall survival (OS), and relapse were analyzed. The cumulative incidences of EBV\u2010DNAemia and EBV\u2010associated disease were 26.9% and 33.3%, respectively. In multivariate analysis, cytomegalovirus (CMV)\u2010DNAemia was confirmed as an independent risk factor associated with EBV\u2010DNAemia and EBV\u2010associated disease. Patients with EBV\u2010associated disease had higher transplant\u2010related mortality (TRM) rates and lower OS rates, but similar relapse rates. Overall, these findings demonstrated the cumulative incidences of EBV\u2010DNAemia and EBV\u2010associated disease and identified correlations of EBV infection with TRM, relapse, and OS. Additionally, CMV\u2010DNAemia was a risk factor for EBV\u2010DNAemia and EBV\u2010associated disease.<\/jats:p>","DOI":"10.1111\/ctr.13856","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T03:29:52Z","timestamp":1584156592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Incidence, risk factors, and clinical outcomes associated with Epstein\u2010Barr virus\u2010DNAemia and Epstein\u2010Barr virus\u2010associated disease in patients after haploidentical allogeneic stem cell transplantation: A single\u2010center study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-1733","authenticated-orcid":false,"given":"Ling","family":"Zhou","sequence":"first","affiliation":[{"name":"The Fifth People\u2019s Hospital of Shanghai, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai Dao\u2010Pei Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dao\u2010Pei","family":"Lu","sequence":"additional","affiliation":[{"name":"The Fifth People\u2019s Hospital of Shanghai, Fudan University Shanghai China"},{"name":"Shanghai Dao\u2010Pei Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.128"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2016.51.1.8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2146"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.05.029"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit391"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.144428"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-019-1123-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_6_11_1","first-page":"1435","article-title":"Association of Epstein\u2010Barr virus infection with allogeneic hematopoietic stem cell transplantation in patients in Portugal","volume":"19","author":"Marinho\u2010Dias J","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03742-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12485"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705445"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12260"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03603-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.035"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12172"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2016.63129"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.01.018"},{"key":"e_1_2_6_21_1","first-page":"278","article-title":"The effect of cytomegalovirus infection on T lymphocytes after allogeneic bone marrow transplantation","volume":"62","author":"W\u00fcrsch AM","year":"1985","journal-title":"Clin Exp Immunol"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.13856","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:22:41Z","timestamp":1694010161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/ctr.13856"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13856","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,7]]},"assertion":[{"value":"2020-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13856"}}