{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:36:20Z","timestamp":1785908180741,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Letermovir was approved in 2017 for prevention of cytomegalovirus (CMV) infection in seropositive (R+) allogeneic hematopoietic cell transplantation (HCT) patients. Post\u2010marketing data with this new agent are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the incidence of both CMV reactivation (any viremia) and clinically significant CMV infection (CS\u2010CMVi; CMV DNAemia leading to preemptive treatment or presence of CMV tissue invasive disease) at days +100 and +200 post\u2010HCT in 25 adult allogeneic HCT patients who received letermovir prophylaxis (until day 100) and a historical control group of 106 CMV R+ allogeneic HCT recipients who underwent CMV preemptive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CMV reactivation within 100\u00a0days post\u2010HCT was lower in the letermovir group vs control group (20% vs 72% respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The 100\u2010day cumulative incidence of CS\u2010CMVi was significantly lower in the letermovir group vs control group (4% vs 59% respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Significantly reduced incidence of CMV reactivation and CS\u2010CMVi was also observed at 200\u00a0days in the letermovir group. No difference in mortality was observed between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms the efficacy of letermovir in preventing CMV reactivation in CMV R+ allogeneic HCT recipients in first 100\u00a0days post\u2010HCT and suggests sustained efficacy after discontinuation of prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13866","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T15:34:58Z","timestamp":1585928098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Clinical \u201creal\u2010world\u201d experience with letermovir for prevention of cytomegalovirus infection in allogeneic hematopoietic cell transplant recipients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-582X","authenticated-orcid":false,"given":"Anthony","family":"Anderson","sequence":"first","affiliation":[{"name":"Sylvester Comprehensive Cancer Center Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Raja","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neisy","family":"Vazquez","sequence":"additional","affiliation":[{"name":"University of Miami Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Morris","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Komanduri","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-5011","authenticated-orcid":false,"given":"Jose","family":"Camargo","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(03)00287-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.11.038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00289-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.3.478"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/652438"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705699"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.02.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-487074"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679639"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016493"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000459"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.388"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13510"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0785-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.01.027"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13187"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45449"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2016.031"},{"key":"e_1_2_7_22_1","article-title":"Outcomes 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