{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:28:42Z","timestamp":1781915322392,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Government grant for clinical research"},{"name":"eSSENCE program"},{"name":"Donation Funds of Skane University Hospital"},{"name":"Anna-Lisa and Sven Eric Lundgrens Foundation"},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"crossref","award":["20180653"],"award-info":[{"award-number":["20180653"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the use of induction therapy has reduced the risk of acute rejection after heart transplantation, its use may be associated with other adverse outcomes. We aimed to examine the effect of no induction (NoInd), induction with basiliximab (BAS), or induction with antithymocyte globulin (ATG) on outcome after heart transplantation. We analyzed data from the International Society for Heart and Lung Transplantation (ISHLT) registry for adult heart transplants performed between 2000 and 2013. The primary outcome was cumulative all\u2010cause mortality, and the secondary outcome was cause\u2010specific death. We identified 27\u00a0369 transplants whose recipients received NoInd (n\u00a0=\u00a015\u00a0688), ATG (n\u00a0=\u00a06830), or BAS (n\u00a0=\u00a04851). Over a median follow\u2010up of 1497\u00a0days, overall 30\u2010day mortality was 5% and 1\u2010year mortality was 11%. Survival after transplant was similar in patients treated with NoInd compared with ATG. The survival was improved using NoInd compared with BAS (log\u2010rank <jats:italic>P<\/jats:italic>\u00a0=\u00a0.040), adjustment HR\u00a0=\u00a01.11 (95% CI, 1.04\u20101.19). Compared to NoInd, BAS was associated with higher risk of graft failure\u2010related deaths, HR\u00a0=\u00a01.27 (95% CI, 1.02\u20101.58), and ATG was associated with higher risk of malignancy\u2010related deaths, HR\u00a0=\u00a01.18 (95% CI, 1.01\u20101.39). Survival of patients who received NoInd was similar to ATG and better compared with BAS. Further, the use of ATG may be associated with increased malignancy\u2010related mortality, compared with NoInd.<\/jats:p>","DOI":"10.1111\/ctr.13871","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T12:39:25Z","timestamp":1586435965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Induction immunosuppression strategies and long\u2010term outcomes after heart transplantation"],"prefix":"10.1111","volume":"34","author":[{"given":"Shahab","family":"Nozohoor","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiothoracic Surgery Lund University and Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-0513","authenticated-orcid":false,"given":"Josef","family":"Stehlik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Utah School of Medicine Salt Lake City Utah USA"},{"name":"The ISHLT Transplant Registry Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-4482","authenticated-orcid":false,"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Unit of Cardiology Department of Medicine Karolinska Institutet and Heart and Vascular Theme Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiothoracic Surgery Lund University and Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Lund, Surgery Lund University and Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-6090","authenticated-orcid":false,"given":"Johan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiothoracic Surgery Lund University and Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"171","article-title":"Induction of immunosuppression with rabbit antithymocyte globulin: five\u2010year experience in cardiac transplantation","volume":"9","author":"Carrier M","year":"1993","journal-title":"Can J Cardiol"},{"issue":"6","key":"e_1_2_8_3_1","first-page":"901","article-title":"OKT3 induction and steroid\u2010free maintenance immunosuppression for treatment of high\u2010risk heart transplant recipients","volume":"10","author":"Prieto M","year":"1991","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12469"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12395"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.04.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9691-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118548387"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990830)18:16<2123::AID-SIM176>3.0.CO;2-4"},{"key":"e_1_2_8_11_1","first-page":"25","article-title":"Survival analysis with time\u2010varying covariates","volume":"7","author":"Weesie J","year":"1998","journal-title":"Stata Tech Bull"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.09.010"},{"issue":"12","key":"e_1_2_8_15_1","first-page":"CD008842","article-title":"Immunosuppressive T\u2010cell antibody induction for heart transplant recipients","volume":"2","author":"Penninga L","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_16_1","first-page":"113","article-title":"Potency testing of anti\u2010lymphocyte globulins: in vitro alternatives for the monkey skin graft assay","volume":"101","author":"Conrad C","year":"1999","journal-title":"Dev Biol Stand"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199504270-00020"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.07.016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.02.016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.08.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13132"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000594"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.13871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.13871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.13871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T04:36:17Z","timestamp":1693888577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.13871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/ctr.13871"],"URL":"https:\/\/doi.org\/10.1111\/ctr.13871","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]},"assertion":[{"value":"2019-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13871"}}