{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:36:41Z","timestamp":1774543001666,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Few studies investigate significant perioperative predictors for long\u2010term renal allograft survival after second kidney transplant (SKT). We compared long\u2010term survival following SKT with primary kidney transplant and determined predictors of renal allograft failure after SKT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcomes of all primary or second kidney transplant recipients at a national kidney transplant center between 1993 and 2017 were reviewed. The primary outcomes measurements were renal allograft survival for both first and second kidney transplants. Secondary outcome measurements were incidence of delayed graft function (DGF), incidence of acute rejection (AR), and predictors for renal allograft survival in SKT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, there were 392 SKTs and 2748 primary kidney transplants performed between 1993 and 2017. The 1\u2010, 5\u2010, and 10\u2010year death\u2010censored graft survival for deceased\u2010donor recipients was 95.3%, 88.7%, and 78.2% for primary kidney transplant and 94.9%, 87.1%, and 74.9% for SKT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0288). Survival of primary renal allograft &lt;6\u00a0years (HR 0.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017), AR episodes (HR 1.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.031), DGF (HR 2.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005), and HLA\u2010DR MM (HR 1.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018) was independent predictors of long\u2010term renal allograft failure after SKT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings may provide important information on long\u2010term survival outcomes after SKT and for identifying patients at risk for long\u2010term renal allograft failure after SKT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13907","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T22:19:43Z","timestamp":1589667583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of long\u2010term renal allograft survival after second kidney transplantation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-8300","authenticated-orcid":false,"given":"John A.","family":"O\u2019Kelly","sequence":"first","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-1475","authenticated-orcid":false,"given":"Niall F.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"},{"name":"Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atakelet A.","family":"Ferede","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran J.","family":"Breen","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"O\u2019Kelly","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5814-0722","authenticated-orcid":false,"given":"Eoin","family":"MacCraith","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Forde","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponnusamy","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Smyth","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilly M.","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Transplant, Urology and Nephrology (TUN) National Kidney Transplant Service (NKTS) Beaumont Hospital Dublin 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