{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:02:14Z","timestamp":1775084534771,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evaluation of pulmonary arterial pressure is crucial among cirrhotic patients, considering that moderate portopulmonary hypertension (POPH) is a contraindication for liver transplantation. Although right heart catheterization (RHC) is the most accurate method to diagnose POPH, it is invasive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study is to evaluate the performance of echocardiography in detecting POPH in liver transplant candidates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Literature search was performed, and pooled sensitivity, specificity, positive likelihood ratio (LR), negative LR, and area under the summary receiver operating curve (AUC) were calculated. Subgroup analyses were performed based on different cutoff values for echocardiography and diagnostic criteria of RHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sensitivity, specificity, positive LR, negative LR, and AUC of echocardiography for detection of POPH were 0.86 (0.74, 0.94), 0.87 (0.84, 0.90), 7.17 (3.59, 14.31), 0.22 (0.13, 0.38), and 0.807 while they were 0.82 (0.74, 0.89), 0.81 (0.78, 0.84), 117.75 (16.03, 865.08), 0.28 (0.16, 0.50), and 0.876for detection of moderate POPH, respectively. Performance of echocardiography was not significantly different in the subgroup analyses of stringency of POPH criteria and pulmonary arterial systolic pressure (ePASP) cutoffs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis supports utilization of echocardiography for screening of POPH. However, RHC remains essential in highly suspicious cases. Echocardiographic data other than ePASP should be evaluated in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.13995","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T18:26:53Z","timestamp":1591122413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Performance of echocardiography for detection of portopulmonary hypertension among liver transplant candidates: Meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-6790","authenticated-orcid":false,"given":"Parker M.","family":"Korbitz","sequence":"first","affiliation":[{"name":"College of Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"College of Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrishikesh","family":"Samant","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Louisiana State University Health Science Center Shreveport LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailender","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta","family":"Jophlin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thammasin","family":"Ingviya","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine Faculty of Medicine Prince of Songkla University Songkhla Thailand"},{"name":"Medical Data Center for Research and Innovation Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-1588","authenticated-orcid":false,"given":"Wuttiporn","family":"Manatsathit","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.08.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500030503"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707185"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2000.6356"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003248"},{"key":"e_1_2_7_7_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins JP","year":"2011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.6.676"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.35554"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4250\/jcvi.2018.26.e2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2805"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50060"},{"key":"e_1_2_7_17_1","first-page":"A2542","article-title":"Utility of trans\u2010thoracic doppler echocardiography in avoiding invasive right heart catheterization in end\u2010stage liver disease patients undergoing evaluation for liver transplantation. 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