{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:39:07Z","timestamp":1787240347121,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In 2005, the Banff committee expanded the \u201cborderline changes\u201d category to include lesions with minimal (&lt;10%) inflammation: \u201ci0\u201d borderline infiltrates. Clinical significance and optimal treatment of i0 borderline infiltrates are not known. Data suggest that i0 borderline infiltrates may have a more favorable prognosis than borderline infiltrates with higher grades of interstitial inflammation. In this single\u2010center, retrospective, observational study, we assessed 90 renal transplant recipients with i0 borderline infiltrates on biopsies indicated for graft dysfunction. We studied the impact of treatment with corticosteroids on allograft function, allograft survival, and patient survival. We found no differences between treated and untreated groups with respect to eGFR at 4\u00a0weeks and 6\u00a0months after biopsy. Follow\u2010up biopsies, available in 67% of patients, were negative for rejection in almost half of all cases, regardless of treatment status. The frequencies of persistent borderline infiltrates (38%) and higher\u2010grade T cell\u2013mediated rejection (1A or greater, 14%) on follow\u2010up biopsies were similar between the two groups. There were no differences in rejection\u2010free allograft survival, death\u2010censored graft failure, or patient mortality among treated vs non\u2010treated i0 borderline patients. Our findings suggest that the natural history of i0 borderline infiltrates, in relatively low immunologic risk patients, is not affected by corticosteroid treatment.<\/jats:p>","DOI":"10.1111\/ctr.14019","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T07:17:58Z","timestamp":1592896678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of borderline infiltrates with minimal inflammation in kidney transplant recipients has no effect on allograft or patient outcomes"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-637X","authenticated-orcid":false,"given":"Leigh\u2010Anne","family":"Dale","sequence":"first","affiliation":[{"name":"New York\u2010Presbyterian\/Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-2754","authenticated-orcid":false,"given":"Corey","family":"Brennan","sequence":"additional","affiliation":[{"name":"The Columbia University Renal Epidemiology Group New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Batal","sequence":"additional","affiliation":[{"name":"Pathology and Cell Biology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata G.","family":"Jain","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Columbia University Medical Center New York NY 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