{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:45:29Z","timestamp":1791265529283,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persistent hyperparathyroidism (pHPT) is frequently seen after transplantation contributing to post\u2010transplant complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective single center analysis to explore the relationship of early pHPT and long\u2010term allograft outcome. Patients were divided into high (N\u00a0=\u00a0153) and low (N\u00a0=\u00a0252) PTH groups based on serum parathyroid hormone (PTH) level 3\u00a0months post\u2010transplant (PTH\u00a0\u2265\u00a0150 and\u00a0&lt;\u00a0150\u00a0pg\/mL, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High PTH was found to be an independent predictor for reduced kidney allograft function up to 3\u00a0years post\u2010transplant. eGFR decreased by 11.4\u00a0mL\/min (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and the odds of having an eGFR\u00a0&lt;\u00a060\u00a0mL\/min 3\u00a0years post\u2010transplant were sixfold higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) in the high compared to the low PTH group. Subgroup analysis based on eGFR 1\u00a0year post\u2010transplant, presence of slow graft function (SGF), and transplant type revealed similar results. High PTH three months post\u2010transplant was also independently associated with an increased risk for overall mortality and for death with a functioning graft (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>pHPT three months post\u2010renal transplantation is an independent predictor for a worse allograft function up to 3\u00a0years post\u2010transplant and a risk factor for mortality. This relationship remains statistically significant after accounting for baseline allograft function, presence of SGF and serum mineral levels abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14085","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T08:04:56Z","timestamp":1600502696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Early persistent hyperparathyroidism post\u2010renal transplantation as a predictor of worse graft function and mortality after transplantation"],"prefix":"10.1111","volume":"34","author":[{"given":"Ofer","family":"Isakov","sequence":"first","affiliation":[{"name":"Department of Internal Medicine \u201cT\u201d Tel Aviv Souraski Medical Center Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Ghinea","sequence":"additional","affiliation":[{"name":"Department of Surgery Sheba Medical Center Tel Aviv University Tel Aviv Israel"},{"name":"Transplant Nephrology Center Sheba Medical Center Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pazit","family":"Beckerman","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sheba Medical Center Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eytan","family":"Mor","sequence":"additional","affiliation":[{"name":"Transplant Nephrology Center Sheba Medical Center Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo V.","family":"Riella","sequence":"additional","affiliation":[{"name":"Renal Division Brigham and Women\u2019s Hospital Harvard Medical School Boston MA 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