{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:26:42Z","timestamp":1793107602440,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study of gender differences may lead into improvement in patient care. We have aimed to identify the gender differences in heart transplantation (HT) of adult HT recipients in Spain and their evolution in a study covering the years 1993\u20132017 in which 6740 HT (20.6% in women) were performed. HT indication rate per million inhabitants was lower in women, remaining basically unchanged during the 25\u2010year study period. HT rate was higher in men, although this decreased over the 25\u2010year study period. Type of heart disease differed in men versus women (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001): ischemic heart disease 47.6% versus 22.5%, dilated cardiomyopathy 41.3% versus 34.6%, or other 36% versus 17.8%, respectively. Men were more frequently diabetics (18% vs. 13.1% <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), hypertensives (33.1% vs. 24% <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and smokers (21.7% vs. 12.9% <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), respectively. Women had more pre\u2010HT malignancies (7.1% vs. 2.8% <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and their clinical status was worse at HT due to renal function and mechanical ventilation. Adjusted survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.198) and most of the mortality\u2010related variables were similar in men and women. Death occurred more frequently in women due to rejection (7.9% vs. 5.1% <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and primary failure (18.2% vs. 12.5% <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and in men due to malignancies (15.1% vs. 6.6% <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p>","DOI":"10.1111\/ctr.14096","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T10:55:38Z","timestamp":1601117738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Gender differences in heart transplantation: Twenty\u2010five year trends in the nationwide Spanish heart transplant registry"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-9896","authenticated-orcid":false,"given":"Mar\u00eda D.","family":"Garc\u00eda\u2010Cos\u00edo","sequence":"first","affiliation":[{"name":"Department of Cardiology Hospital Universitario 12 de Octubre, Instituto de Investigaci\u00f3n Sanitaria 12 de Octubre (imas12) Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Cardiovascular (CIBERCV) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Gonz\u00e1lez\u2010Vilchez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Marqu\u00e9s de Valdecilla Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"L\u00f3pez\u2010Vilella","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitari I Politecnic La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Barge\u2010Caballero","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complejo Hospitalario Universitario de A Coru\u00f1a A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"G\u00f3mez\u2010Bueno","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mart\u00ednez\u2010Selles","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Cardiovascular (CIBERCV) Madrid Spain"},{"name":"Department of Cardiology Hospital General Universitario Gregorio Mara\u00f1\u00f3n Universidad Europea Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Ariz\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Reina Sof\u00eda Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Rangel Sousa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Virgen Del Roc\u00edo Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Gonz\u00e1lez\u2010Costello","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitari De Bellvitge Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5955-2748","authenticated-orcid":false,"given":"Sonia","family":"Mirabet","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Santa Creu I Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"P\u00e9rez\u2010Villa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednic I Provincial Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"D\u00edaz\u2010Molina","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Central De Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"R\u00e1bago","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Cl\u00ednica Universidad De Navarra Navarra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Portol\u00e9s Ocampo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Miguel Servet Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"de la Fuente\u2010Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario De Valladolid Valladolid 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