{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:18:21Z","timestamp":1767093501065,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antihuman leukocyte antigen (HLA) antibodies restrict the access to cardiac allografts. Desensitization therapy is a major challenge in patients with cardiogenic shock waiting for urgent heart transplantation (HT). We retrospectively reviewed six patients (mean age of 37.5\u00a0years [16\u201370]) who underwent plasmapheresis (PP) under extracorporeal membrane oxygenation (ECMO) before transplant between January 2017 and September 2018. The average duration of follow\u2010up was 25\u00a0months [20\u201332]. Mean fluorescence intensity (MFI) of HLA\u2010specific antibodies was reported as follows: score 4 for MFI\u00a0&lt;\u00a01000, score 6 for 1000\u00a0&lt;\u00a0MFI\u00a0&lt;\u00a03000 and score 8 for MFI\u00a0&gt;\u00a03000. The mean duration of ECMO support was 29\u00a0days [1\u201374] and 6.8 [1\u201329] PP sessions were performed per patient before transplant. The mean number of HLA\u2010specific antibodies before HT was 9.6 for score 6 [4\u201313] and 5.8 for score 8 [1\u201312]. Four patients had major complications after transplantation (2 hemorrhagic shocks, 5 infectious events). Mean MFI reduction rate was 94% [79\u2013100] for Class I and 44.2% for Class II [0\u201383]. Hospital survival was 100%, and early antibody\u2010mediated rejection was diagnosed in one patient at 7\u00a0days after HT. Plasmapheresis under ECMO support was associated with favorable early outcomes in highly sensitized candidates for urgent heart transplantation.<\/jats:p>","DOI":"10.1111\/ctr.14146","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T14:15:01Z","timestamp":1605104101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Urgent desensitization in patients bridged to heart transplantation under extracorporeal membrane oxygenation support: A preliminary experience"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-3176","authenticated-orcid":false,"given":"Julien","family":"Guihaire","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Marie Lannelongue Hospital Groupe Hospitalier Paris Saint Joseph University of Paris Saclay School of Medicine  Le Plessis Robinson 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Tram","family":"To","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Marie Lannelongue Hospital Groupe Hospitalier Paris Saint Joseph University of Paris Saclay School of Medicine  Le Plessis Robinson France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"Potier","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Marie Lannelongue Hospital Groupe Hospitalier Paris Saint Joseph University of Paris Saclay School of Medicine  Le Plessis Robinson France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00efra","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Marie Lannelongue Hospital Groupe Hospitalier Paris Saint Joseph University of Paris Saclay School of Medicine  Le Plessis Robinson 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Deleuze","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Marie Lannelongue Hospital Groupe Hospitalier Paris Saint Joseph University of Paris Saclay School of Medicine  Le Plessis Robinson 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