{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:05:09Z","timestamp":1770825909899,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rituximab has been proposed as induction therapy in kidney transplant recipients (KTRs) with preformed donor\u2010specific antibodies (DSA) or a positive flow cross\u2010match. We here evaluated whether adding rituximab was associated with a higher incidence of post\u2010transplant malignancies (PTM) due to greater immunosuppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Forty\u2010eight HLA\u2010sensitized KTRs received induction therapy with anti\u2010thymocyte globulin (ATG) and rituximab because of preformed DSA or a positive flow cross\u2010match (RTX group). They were compared with a control group of 154 patients receiving ATG alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine of 202 (19.3%) patients developed PTM; the rate was similar in the RTX and no\u2010RTX groups (14.6% vs. 20.8%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.3). The distributions of the types of cancer were similar between the two groups, with the majority being non\u2010melanoma skin cancer (NMSC, <jats:italic>n<\/jats:italic>\u00a0=\u00a024). The risk factors for PTM were male gender, age, history of cancer, and azathioprine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data do not indicate a higher rate of post\u2010transplantation de novo malignancies after kidney transplantation in high\u2010immunological risk patients who received induction therapy based on ATG and rituximab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14171","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T09:40:09Z","timestamp":1606556409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The incidence of post\u2010transplant malignancies in kidney transplant recipients treated with Rituximab"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-1444","authenticated-orcid":false,"given":"Thomas","family":"Bachelet","sequence":"first","affiliation":[{"name":"Clinique Saint\u2010Augustin\u2010CTMR  Bordeaux ELSAN France"},{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Visentin","sequence":"additional","affiliation":[{"name":"Immunology and Immunogenetics Laboratory Bordeaux University Hospital  Bordeaux France"},{"name":"ImmunoConcEpT UMR 5164 Bordeaux University CNRS  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippine","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Taton","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwendaline","family":"Guidicelli","sequence":"additional","affiliation":[{"name":"Immunology and Immunogenetics Laboratory Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"},{"name":"ImmunoConcEpT UMR 5164 Bordeaux University CNRS  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Merville","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"},{"name":"ImmunoConcEpT UMR 5164 Bordeaux University CNRS  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Couzi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Bordeaux University Hospital  Bordeaux France"},{"name":"ImmunoConcEpT UMR 5164 Bordeaux University CNRS  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070664"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012376"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31595-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030368"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01178.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181da1cc3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000064"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12267"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.261"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02785.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12535"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.09.042"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0022-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20781"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.5137"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03751.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001280"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08496-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12165"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2234-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000442773.38510.32"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000449"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139479"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000469"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.11.006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001239"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13382"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001385"},{"key":"e_1_2_9_31_1","first-page":"3420","article-title":"Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression","volume":"118","author":"Matsushita T","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-266668"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01823.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015040373"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_817_17"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.3.7963"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204166"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.11.008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.487"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03961.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6679"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001192"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001286"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12864"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03790417"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2015.966694"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030250"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13092"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01521.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12631"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008101072"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12813"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.253"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T19:01:37Z","timestamp":1693681297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,12]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/ctr.14171"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14171","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,12]]},"assertion":[{"value":"2020-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14171"}}