{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:38:14Z","timestamp":1761514694258,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The spectrum of human adenovirus (HAdV)\u2013related disease is broad, and the virus acts on many organs and systems in hematopoietic stem cell transplantation (HSCT) recipients. We aimed to evaluate the effect of HAdV\u2010DNA positivity with clinical and laboratory findings 4\u00a0months after HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively investigated HAdV\u2010DNA in 153 HSCT recipients (\u226418\u00a0years) by quantitative real\u2010time polymerase chain reaction (RealStar; Altona Diagnostics). The results of samples from January 2014 to December 2017 are included. HAdV\u2010DNA was positive for at least one sample type in 50 (32.67%) patients. HAdV\u2010DNA positivity rate was 8.92% (<jats:italic>N<\/jats:italic>: 145\/1625), 40.25% (<jats:italic>N<\/jats:italic>: 64\/159), and 25% (<jats:italic>N<\/jats:italic>: 2\/8) for plasma, stool, and urine samples, respectively. HAdV\u2010DNA was positive in the plasma of 38 (24.83%) patients at a median 16 (range: 1\u201358\u00a0days) days after HSCT. The mortality rate was 23.68% and 6.95% in plasma HAdV\u2010positive and HAdV\u2010negative patients (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.014). Moreover, HAdV\u2010DNA positivity had an impact on overall survival for allogeneic\u2010HSCT (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.013), with the cumulative effect including graft\u2010versus\u2010host disease state in multivariate analysis (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma HAdV\u2010DNA positivity is a potential influencer that decreases survival in the early post\u2010transplant period. Due to the high mortality rates, close monitoring is required of HAdV infections after HSCT with sensitive methods, especially at the early stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14209","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T07:47:39Z","timestamp":1608968859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Follow\u2010up of human adenovirus viral load in pediatric hematopoietic stem cell transplant recipients"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-2962","authenticated-orcid":false,"given":"Bilal Olcay","family":"Peker","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Izmir Katip \u00c7elebi University Atat\u00fcrk Training and Research Hospital  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclen","family":"T\u00fcys\u00fcz Kintrup","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Akdeniz University Medical Faculty  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-4989","authenticated-orcid":false,"given":"\u0130mran","family":"Sa\u011fl\u0131k","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Uluda\u011f University Medical Faculty  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia","family":"Can Sar\u0131no\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Marmara University Pendik Research and Training Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Akdeniz University Medical Faculty  Antalya 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