{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:47:25Z","timestamp":1787320045192,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK007470"],"award-info":[{"award-number":["DK007470"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK097836"],"award-info":[{"award-number":["R01 DK097836"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK108329"],"award-info":[{"award-number":["R01 DK108329"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Variants in apolipoprotein L1 (\n                    <jats:italic>APOL1<\/jats:italic>\n                    ) gene are associated with nondiabetic kidney diseases in black subjects and reduced kidney transplant graft survival. Living and deceased black kidney donors (n\u00a0=\u00a0107) were genotyped for\n                    <jats:italic>APOL1<\/jats:italic>\n                    variants. To determine whether allografts from high\u2010risk\n                    <jats:italic>APOL1<\/jats:italic>\n                    donors have reduced podocyte densities contributing to allograft failure, we morphometrically estimated podocyte number, glomerular volume, and podocyte density. We compared allograft loss and eGFR trajectories stratified by\n                    <jats:italic>APOL1<\/jats:italic>\n                    high\u2010risk and low\u2010risk genotypes. Demographic characteristics were similar in high\u2010risk (n\u00a0=\u00a016) and low\u2010risk (n\u00a0=\u00a091) donors. Podocyte density was significantly lower in high\u2010risk than low\u2010risk donors (108\u00a0\u00b1\u00a026 vs 127\u00a0\u00b1\u00a040 podocytes\/10\n                    <jats:sup>6<\/jats:sup>\n                    um\n                    <jats:sup>3<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.03). Kaplan\u2010Meier graft survival (high\u2010risk 61% vs. low\u2010risk 91%, p\u2010value\u00a0=\u00a00.049) and multivariable Cox models (hazard ratio\u00a0=\u00a02.6; 95% CI, 0.9\u20107.8) revealed higher graft loss in recipients of\n                    <jats:italic>APOL1<\/jats:italic>\n                    high\u2010risk allografts over 48\u00a0months. More rapid eGFR decline was seen in recipients of high\u2010risk\n                    <jats:italic>APOL1<\/jats:italic>\n                    allografts (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). At 60\u00a0months, eGFR was 27 vs. 51\u00a0mL\/min\/1.73\u00a0min\n                    <jats:sup>2<\/jats:sup>\n                    in recipients of\n                    <jats:italic>APOL1<\/jats:italic>\n                    high\u2010risk vs low\u2010risk kidney allografts, respectively. Kidneys from high\u2010risk\n                    <jats:italic>APOL1<\/jats:italic>\n                    donors had worse outcomes versus low\u2010risk\n                    <jats:italic>APOL1<\/jats:italic>\n                    genotypes. Lower podocyte density in kidneys from high\u2010risk APOL1 donors may increase susceptibility to CKD from subsequent stresses in both the recipients and donors.\n                  <\/jats:p>","DOI":"10.1111\/ctr.14234","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T03:21:32Z","timestamp":1611890492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Podocyte density is reduced in kidney allografts with high\u2010risk\n                    <i>APOL1<\/i>\n                    genotypes at transplantation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6078-8392","authenticated-orcid":false,"given":"Dhruti P.","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Nephrology UNC Kidney Center University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad S.","family":"Zaky","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse D.","family":"Schold","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland OH USA"},{"name":"Quantitative Health Sciences Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leal C.","family":"Herlitz","sequence":"additional","affiliation":[{"name":"Pathology and Lab Medicine Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"El\u2010Rifai","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Drawz","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Bruggeman","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland OH USA"},{"name":"Lerner Research Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barisoni","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Medicine Division of Nephrology Duke University School of Medicine Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Nephrology UNC Kidney Center University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Nephrology UNC Kidney Center University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland OH USA"},{"name":"Lerner Research Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio D.","family":"Poggio","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland OH USA"},{"name":"Lerner Research Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-9168","authenticated-orcid":false,"given":"John R.","family":"Sedor","sequence":"additional","affiliation":[{"name":"Glickman Urology and Kidney Institute Cleveland Clinic Cleveland OH USA"},{"name":"Lerner Research Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016111262"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.07.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2017.07.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016121322"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015111220"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224408"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.04.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4287"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016050550"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016050546"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP86S116"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4362"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13223"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04033.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000969"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86943"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92581"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011010069"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080859"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193032"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030287"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012030271"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs313"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14234","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:01:16Z","timestamp":1693566076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/ctr.14234"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14234","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"assertion":[{"value":"2020-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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