{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:49:40Z","timestamp":1782604180348,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010neutrophil cytoplasmic antibody (ANCA)\u2013associated vasculitides are uncommon causes of kidney failure. In kidney transplant recipients who developed kidney failure secondary to ANCA\u2010associated vasculitis, disease recurrence is unlikely due to ongoing immunosuppression, and patients generally have good immunological outcomes. This study compared transplant outcomes between ANCA\u2010associated vasculitis and other etiologies of kidney disease. All 18\u00a0901 adult kidney transplant recipients (1990\u20102018) were ascertained from the ANZDATA Registry. Cox proportional hazards models were used to compare allograft failure between etiologies of kidney disease. Of 254 participants whose primary disease was ANCA\u2010associated vasculitis, 95 (37%) developed allograft failure; of those who developed graft failure, 62 (65%) died with a functioning allograft. Compared with patients with IgA nephropathy, those with ANCA\u2010associated vasculitis had higher rates of all\u2010cause allograft failure (HR: 1.4, 95% CI: 1.2\u20101.7); however, rates of death\u2010censored allograft failure were similar (HR: 1.0, 95% CI: 0.7\u20101.4). The most frequent causes of death in the ANCA\u2010vasculitis group who died with a functioning graft were infection (23%) and malignancy (36%). Kidney transplant recipients who developed kidney failure secondary to ANCA\u2010associated vasculitis may have had a higher risk of dying due to complications of immunosuppression compared with most other causes of kidney failure; however, they also had lower risks of disease recurrence and rejection.<\/jats:p>","DOI":"10.1111\/ctr.14235","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T18:15:34Z","timestamp":1612376134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Allograft failure in kidney transplant recipients who developed kidney failure secondary to ANCA\u2010associated vasculitis"],"prefix":"10.1111","volume":"35","author":[{"given":"Lukas","family":"Kuhnel","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Queensland Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-9913","authenticated-orcid":false,"given":"Robert J.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland Brisbane QLD Australia"},{"name":"Translational Research Institute Brisbane QLD Australia"},{"name":"Department of Nephrology Princess Alexandra Hospital Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross S.","family":"Francis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland Brisbane QLD Australia"},{"name":"Translational Research Institute Brisbane QLD Australia"},{"name":"Department of Nephrology Princess Alexandra Hospital Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"ANZDATA 42nd 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