{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:03:07Z","timestamp":1785520987645,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770645"],"award-info":[{"award-number":["81770645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health and Family Planning Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["2018260134"],"award-info":[{"award-number":["2018260134"]}],"id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to assess how pre\u2010transplant dialysis duration affects transplant outcomes after simultaneous pancreas\u2010kidney transplant (SPK) in patients with type 1 diabetes mellitus (T1DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of 6887 T1DM patients who underwent SPK transplantation between 2008 and 2018 were obtained from the Scientific Registry of Transplant Recipients database. According to pre\u2010transplant dialysis duration, the patients were divided into the preemptive SPK, 0\u20102\u00a0years, 2\u20105\u00a0years, and &gt;5\u00a0years dialysis groups. Kaplan\u2010Meier survival analysis was performed to compare patient and graft survival among the groups. Univariate and multivariate Cox regression analyses were used to identify predictors of transplant outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up period was 56.7\u00a0\u00b1\u00a034.7\u00a0months. Compared with no dialysis or preemptive SPK, dialysis for 0\u20102\u00a0years was not significantly associated with patient or kidney graft survival, while long\u2010term dialysis of 2\u20105\u00a0years and &gt;5\u00a0years was significantly associated with increased risk of death and kidney graft failure. However, the duration of dialysis was not associated with pancreas graft survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term dialysis duration before SPK transplant is an independent predictor of patient death and kidney graft failure in T1DM patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14238","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T23:50:44Z","timestamp":1612396244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of dialysis duration on outcomes of simultaneous pancreas\u2010kidney transplant"],"prefix":"10.1111","volume":"35","author":[{"given":"Yinlei","family":"Dong","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery Department of Surgery School of Medicine First Affiliated Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery Department of Surgery School of Medicine First Affiliated Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery Department of Surgery School of Medicine First Affiliated Hospital Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xiang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery Department of Surgery School of Medicine First Affiliated Hospital Zhejiang University  Hangzhou 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