{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:38:25Z","timestamp":1790537905832,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney transplant (KT) outcomes from high kidney donor profile index (KDPI \u226585%) donors with acute kidney injury (AKI) remain underreported. KT from 172 high KDPI Acute Kidney Injury Network (AKIN) stage 0\u20101 donors and 76 high KDPI AKIN stage 2\u20103 donors from a single center were retrospectively assessed. The AKIN 2\u20103 cohort had more delayed graft function (71% vs. 37%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). At one year, there were no differences in the estimated glomerular filtration rate (44\u00a0\u00b1\u00a017 vs. 46\u00a0\u00b1\u00a018, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.42) or fibrosis on protocol biopsy (ci, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.85). Donor terminal creatinine (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.59) and length of delayed graft function (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.39) did not impact one\u2010year eGFR. There were more primary nonfunction (PNF) events in the high KDPI AKIN 2\u20103 group (5.3% vs. 0.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). With a median follow\u2010up of 3.8\u00a0years, one\u2010year death\u2010censored graft failure was 3.5% for AKIN 0\u20101 and 14.5% for AKIN 2\u20103 (HR 2.40, 95% CI 1.24\u20104.63, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Although AKIN stage 2\u20103 high KDPI kidneys had comparable one\u2010year eGFR to AKIN stage 0\u20101 high KDPI kidneys, there were more PNF occurrences and one\u2010year death\u2010censored graft survival was reduced. Given these findings, additional precautions should be undertaken when assessing and utilizing kidneys from severe AKI high KDPI donors.<\/jats:p>","DOI":"10.1111\/ctr.14279","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T18:20:30Z","timestamp":1615400430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Transplant outcomes using kidneys from high KDPI acute kidney injury donors"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-9519","authenticated-orcid":false,"given":"Caroline C.","family":"Jadlowiec","sequence":"first","affiliation":[{"name":"Division of Transplant Surgery Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael A.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Ninan","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika M.","family":"Das","sequence":"additional","affiliation":[{"name":"Alix School of Medicine Mayo Clinic  Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Khamash","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-2014","authenticated-orcid":false,"given":"Amit K.","family":"Mathur","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Singer","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adyr","family":"Moss","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunam S.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond L.","family":"Heilman","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic  Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200211150-00014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13867"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01852.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15653"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13260"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002792"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01241.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2013.08.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829807d1"},{"key":"e_1_2_7_11_1","unstructured":"UNOS.Annual kidney allocation calculator updates.https:\/\/unos.org\/news\/annual\u2010kidney\u2010allocation\u2010calc\u2010updates\/. 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