{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:43:02Z","timestamp":1774006982086,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The virologic and histologic outcomes of a hepatitis C virus (HCV)\u2013infected liver graft into an HCV\u2010negative recipient are not well understood. We aimed to evaluate the\u00a0sustained virologic response\u00a0(SVR)\u00a0rate and the liver histology at 1\u00a0year post\u2010Orthotopic liver transplantation (OLT) with an HCV\u2010infected graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 33 patients received the HCV antibody (Ab)+\/nucleic acid amplification test (NAT)+ graft. Of these patients, 23 were HCV\u2010negative recipients and 10 were HCV\u2010positive recipients. The 1\u2010year biopsy data were available for 24 patients: 15 patients in HCV\u2010negative group who received an HCV Ab+\/NAT+graft and 9 patients in HCV\u2010positive group who received an HCV Ab+\/NAT+ graft. Patients with (+) HCV ribonucleic acid (RNA) were started on\u00a0direct\u2010acting antiviral (DAA) treatment approximately 107\u00a0days after OLT using either a Glecaprevir\u2010Pibrentasvir or Sofosbuvir\u2010Velpatasvir or Sofosbuvir\u2010Ledipasvir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a033) were treated with\u00a0DAA and achieved SVR. The 1\u2010year post\u2010OLT liver biopsies were available in 24 patients: 9 patients had F1 and F2 fibrosis and 17 patients had minimal to moderate inflammation.\u00a0There was no statistical difference in fibrosis and inflammation between the HCV\u2010negative vs. HCV\u2010positive recipients. All patients who received the NAT+ graft developed viremia and subsequently achieved SVR with treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 1\u00a0year protocol liver biopsy, patients had inflammation consistent with viral hepatitis despite the successful eradication of HCV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14281","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T19:58:15Z","timestamp":1615406295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Transplantation of liver from hepatitis C\u2013infected donors to hepatitis C RNA\u2013negative recipients: Histological and virologic outcome"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4167-6643","authenticated-orcid":false,"given":"Satheesh P.","family":"Nair","sequence":"first","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"},{"name":"Department of Medicine University of Tennessee Health Science Center  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemnishil K.","family":"Marella","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"},{"name":"Department of Medicine University of Tennessee Health Science Center  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict","family":"Maliakkal","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"},{"name":"Department of Medicine University of Tennessee Health Science Center  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Snyder","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Handley","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiten P.","family":"Kothadia","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"},{"name":"Department of Medicine University of Tennessee Health Science Center  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6783-3854","authenticated-orcid":false,"given":"Bilal","family":"Ali","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0153-2829","authenticated-orcid":false,"given":"Sanjaya K.","family":"Satapathy","sequence":"additional","affiliation":[{"name":"Department of Medicine Zucker School of Medicine at Hofstra Sandra Atlas Bass Center for Liver Diseases &amp; Transplantation Northshore University Hospital\/Northwell Health  Manhasset NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-330X","authenticated-orcid":false,"given":"Miklos Z.","family":"Molnar","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Tennessee Health Science Center  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Tennessee Health Science Center  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Helmick","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute University of Tennessee Health Science Center' Methodist University Hospital  Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey","family":"Eymard","sequence":"additional","affiliation":[{"name":"James D. 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