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There is uncertainty about the safety of solid organ transplantation in patients with a prior history of melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review studies reporting patients with a history of melanoma before solid organ transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic searches of Medline, Embase, and the Cochrane library up to March 2020. All study designs, in any language and without sample size restriction, were eligible for inclusion. Risk of bias was assessed using established tools, and meta\u2010analysis was performed using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 41 studies reporting 703\u00a0100 transplant recipients and 1692 had pre\u2010transplantation melanomas. Risk of death, expressed as a hazard ratio, in patients with pre\u2010transplantation melanoma relative to those without prior melanoma, was 1.32 (95% CI: 1.09\u20131.59). After transplantation, 13.1% of patients with pre\u2010transplantation melanoma developed new or recurrent melanoma (IQR: 4.8%\u201318.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Around 1\u2010in\u2010400 transplant recipients had a prior history of melanoma. This was associated with a greater than 1\u2010in\u201010 risk of new or recurrent melanoma after transplantation and an increased risk of death. A 5\u2010year waiting time between a melanoma diagnosis and transplantation has been recommended based on historic registry data, but very little additional information is available to justify or revise this.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14287","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T13:57:08Z","timestamp":1615816628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Organ transplantation and outcomes in patients with a past history of melanoma: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"given":"Gabrielle Jean","family":"Williams","sequence":"first","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela C.","family":"Webster","sequence":"additional","affiliation":[{"name":"School of Public 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