{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:12:31Z","timestamp":1792977151662,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK090358"],"award-info":[{"award-number":["R01 DK090358"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK007013"],"award-info":[{"award-number":["T32 DK007013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002377"],"award-info":[{"award-number":["UL1 TR002377"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The medium\u2010 to long\u2010term outcomes of living kidney donors with hypertension compared to normotensive donors are not well understood, especially with the recent changes in hypertension guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied a cohort of 950 living kidney donors using different definitions of hypertension based on either \u2265140\/90 or \u2265130\/80\u00a0mmHg thresholds and based on either office or ambulatory blood pressure readings. Microstructural features on kidney biopsy at the time of donation were compared using different definitions of hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for years of follow\u2010up, age, sex, and baseline eGFR, hypertension (by any definition) did not significantly predict an eGFR\u00a0&lt;\u00a045\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> at a median follow\u2010up of 10\u00a0years postdonation, though there was a borderline association with ambulatory blood pressure\u00a0\u2265\u00a0130\/80\u00a0mmHg predicting a 40% decline in eGFR (OR\u00a0=\u00a01.53, 1.00\u20132.36; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.051). Proteinuria was predicted by office blood pressure\u00a0\u2265\u00a0140\/90\u00a0mmHg and by nondipper profile on nocturnal ambulatory blood pressure measurements. At the time of donation, larger glomeruli and arterial hyalinosis on biopsy were associated with hypertension defined by either \u2265140\/90 or \u2265130\/80\u00a0mmHg (by office or ambulatory measurements). Nocturnal nondipper status was associated with larger glomeruli size but not arteriolar hyalinosis when compared to dippers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In programs that accept donors with controlled hypertension, various definitions of hypertension are associated with histological findings in the donated kidney, but none predict a clinically significant decline in kidney function 10\u00a0years after donation. These data support allowing healthy individuals with controlled hypertension to donate a kidney. However, donors with office hypertension (\u2265140\/90\u00a0mmHg) and nondippers (regardless of hypertension status) are at greater long\u2010term risk for proteinuria, and particularly for these donors, longer follow\u2010up is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14293","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T01:35:32Z","timestamp":1616290532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Renal function outcomes and kidney biopsy features of living kidney donors with hypertension"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-3418","authenticated-orcid":false,"given":"Massini A.","family":"Merzkani","sequence":"first","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Mayo Clinic Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Mullan","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics &amp; Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Denic","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-9806","authenticated-orcid":false,"given":"Matthew","family":"D'Costa","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Mayo Clinic Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Iverson","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics &amp; Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Kremers","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics &amp; Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam P.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Textor","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Mayo Clinic Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J.","family":"Taler","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Mayo Clinic Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-0792","authenticated-orcid":false,"given":"Mark D.","family":"Stegall","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Augustine","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3165-5184","authenticated-orcid":false,"given":"Naim","family":"Issa","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Mayo Clinic Rochester MN USA"},{"name":"William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Rule","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15672"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.12.1236"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60674-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1203"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804883"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.285141"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.460"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.8.1003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008060621"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-9-201005040-00006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000077346.92039.9C"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000128168.97735.B3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15259"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.09.026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40472-016-0091-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"issue":"19","key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"e127\u2010e248","DOI":"10.1016\/j.jacc.2017.11.006","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton PK","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2016-045"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92867-X"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.2.528"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.12.029"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016020154"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002215"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.01.019"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318240e9b9"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030304"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182a7d5b2"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.14031118"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00174-X"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.05.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.01.017"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0155-9"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06201208"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp074"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(01)00238-7"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.130"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2015.01.003"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000145180.38707.84"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92624-O"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94334"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft480"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015091018"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.08.041"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv072"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14293","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:07:02Z","timestamp":1693364822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/ctr.14293"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14293","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,30]]},"assertion":[{"value":"2020-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14293"}}