{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:19:55Z","timestamp":1753877995389,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>ABO\u2010incompatible hematopoietic stem cell transplantations (HSCTs) are widely practiced; however, the delay in erythrocyte engraftment can be problematic. While erythrocyte engraftment is usually indicated by an increase in reticulocyte levels without the need for erythrocyte transfusions, the disappearance of recipient\u2010derived anti\u2010A\/B isoagglutinin and detection of donor\u2010derived A\/B antigens can also be used as other parameters. We conducted a retrospective analysis of 68 ABO\u2010incompatible HSCTs, focusing on major and bidirectional mismatch. We analyzed known clinical risk factors associated with delayed erythrocyte engraftment using the three parameters (disappearance of anti\u2010A\/B isoagglutinin in recipient, detection of donor\u2010derived A\/B antigen, and reticulocyte levels &gt;1%). Although the three parameters were well correlated, the results showed heterogeneity when analyzing the associated risk factors for delayed erythrocyte engraftment. In the analysis of all cases, the requirement for an HLA\u2010matched platelet transfusion was a common risk factor. Furthermore, erythrocyte engraftment was slower in adults than in children. In adults, cytomegalovirus antigenemia was a risk factor for two parameters; however, in children, underlying disease was a common risk factor for all parameters. There is a complex relationship between erythrocyte engraftment and various factors related to HSCTs. Our results suggest that greater accuracy is possible by using analysis methods other than the measurement of reticulocyte levels.<\/jats:p>","DOI":"10.1111\/ctr.14300","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T09:19:47Z","timestamp":1616836787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of risk factors associated with erythrocyte engraftment after ABO\u2010incompatible hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-0958","authenticated-orcid":false,"given":"Ryu","family":"Yanagisawa","sequence":"first","affiliation":[{"name":"Division of Blood Transfusion Shinshu University Hospital Matsumoto Japan"},{"name":"Center for Advanced Cell Therapy Shinshu University Hospital Matsumoto 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