{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:58:20Z","timestamp":1791475100703,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002037","name":"CSL Behring Foundation for Research and Advancement of Patient Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antibody\u2010mediated rejection (AMR) is a leading cause of kidney allograft failure, but its incidence, risk factors, and outcomes are not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Ovid MEDLINE, Cochrane, EMBASE, and Scopus from January 2000 to January 2020 to identify published cohorts of \u2265500 incident adult or 75 pediatric kidney transplant recipients followed for \u22651\u00a0year post\u2010transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At least two reviewers screened 5061 articles and abstracts; 28 met inclusion criteria. Incidence of acute AMR was 1.1%\u201021.5%; most studies reported 3%\u201012% incidence, usually within the first year post\u2010transplant. Few studies reported chronic AMR incidence, from 7.5%\u201020.1% up to 10 years. Almost all patients with acute or chronic AMR received corticosteroids and intravenous immunoglobulin; most received plasmapheresis, and approximately half with rituximab. Most studies examining death\u2010censored graft failure identified AMR as an independent risk factor. Few reported refractory AMR rates or outcomes, and none examined costs. Most studies were single\u2010center and varied greatly in design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cohort studies of kidney transplant recipients demonstrate that AMR is common and associated with increased risk of death\u2010censored graft failure, but studies vary widely regarding populations, definitions, and reported incidence. Gaps remain in our understanding of refractory AMR, its costs, and resulting quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.14320","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T13:07:13Z","timestamp":1618664833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Incidence, risk factors, treatment, and consequences of antibody\u2010mediated kidney transplant rejection: A systematic review"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-0141","authenticated-orcid":false,"given":"Allyson","family":"Hart","sequence":"first","affiliation":[{"name":"Department of Medicine Hennepin County Medical Center Hennepin Healthcare Minneapolis MN USA"},{"name":"University of Minnesota Medical School Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devender","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Jane","family":"Brown","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaison Health Sciences Libraries University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Hennepin County Medical Center Hennepin Healthcare Minneapolis MN USA"},{"name":"University of Minnesota Medical School Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram L.","family":"Kasiske","sequence":"additional","affiliation":[{"name":"Department of Medicine Hennepin County Medical Center Hennepin Healthcare Minneapolis MN 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