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Unfortunately, successful long\u2010term outcomes of heart transplantation can be hindered by immune\u2010mediated rejection of the cardiac allograft, specifically acute cellular rejection, antibody\u2010mediated rejection, and cardiac allograft vasculopathy. Extracorporeal photopheresis is a cellular immunotherapy that involves the collection and treatment of white blood cells contained in the buffy coat with a photoactive psoralen compound, 8\u2010methoxy psoralen, and subsequent irradiation with ultraviolet A light. This process is thought to cause DNA and RNA crosslinking, ultimately leading to cell destruction. The true mechanism of therapeutic action remains unknown. In the last three decades, extracorporeal photopheresis has shown promising results and is indicated for a variety of conditions. The American Society for Apheresis currently recommends the use of extracorporeal photopheresis for the treatment of cutaneous T\u2010cell lymphoma, scleroderma, psoriasis, pemphigus vulgaris, atopic dermatitis, graft\u2010versus\u2010host disease, Crohn's disease, nephrogenic systemic fibrosis, and solid organ rejection in heart, lung, and liver transplantation. In this review, we aim to explore the proposed effects of extracorporeal photopheresis and to summarize published data on its use as a prophylactic and therapy in heart transplant rejection.<\/jats:p>","DOI":"10.1111\/ctr.14333","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T14:39:24Z","timestamp":1619707164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Extracorporeal photopheresis and its role in heart transplant rejection: prophylaxis and treatment"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-2400","authenticated-orcid":false,"given":"Sharon","family":"Slomovich","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Columbia University New York NY 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