{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:51:47Z","timestamp":1779202307250,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2018027"],"award-info":[{"award-number":["2018027"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Optimal iron management is crucial to marginal patients such as heart transplant recipients. As inflammatory mechanisms are present in transplant recipients, the definition of iron deficiency used in the general population might not be appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the prevalence and determinants of iron deficiency in Norwegian heart transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We consecutively assessed iron parameters in all Norwegian heart transplant recipients at their annual follow\u2010up. Several definitions of iron deficiency suggested in the literature were assessed: ferritin &lt;100\u00a0\u00b5g\/L, or ferritin 100\u2010300\u00a0\u00b5g\/L combined with transferrin saturation of &lt;20% (ID<jats:sub>HF<\/jats:sub>); ferritin &lt;100\u00a0\u00b5g\/L (ID<jats:sub>F100<\/jats:sub>); transferrin saturation of &lt;20% (ID<jats:sub>Tsat<\/jats:sub>), and ferritin &lt;30\u00a0\u00b5g\/L (ID<jats:sub>F30<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>179 of 378 heart transplant recipients (47%) had iron deficiency defined as ID<jats:sub>HF<\/jats:sub>. 152 patients (40%) had ID<jats:sub>F100<\/jats:sub>, and 103 patients (27%) had ID<jats:sub>Tsat<\/jats:sub>. 17 patients (5%) had ID<jats:sub>F30<\/jats:sub>. 88 patients (23%) had a C\u2010reactive protein (CRP) &gt;5.0\u00a0\u00b5g\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron deficiency defined as ID<jats:sub>HF<\/jats:sub>, ID<jats:sub>F100,<\/jats:sub> or ID<jats:sub>Tsat<\/jats:sub> is prevalent in the heart transplant population, while ID<jats:sub>F30<\/jats:sub> is not. Further research is required to identify the mechanisms of iron homeostasis in heart transplant recipients and to establish a definition of iron deficiency suitable for this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14346","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T08:42:46Z","timestamp":1620636166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of iron deficiency in heart transplant recipients"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-2648","authenticated-orcid":false,"given":"Kristine V","family":"Brautaset Englund","sequence":"first","affiliation":[{"name":"Department of Cardiology Oslo University Hospital  Oslo Norway"},{"name":"University of Oslo  Oslo Norway"},{"name":"K.G.Jebsen Cardiac Research Center and Center for Heart Failure Research Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte M","family":"\u00d8stby","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gry","family":"Tj\u00f8nn\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar","family":"Gude","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital  Oslo Norway"},{"name":"K.G.Jebsen Cardiac Research Center and Center for Heart Failure Research Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne K","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital  Oslo Norway"},{"name":"K.G.Jebsen Cardiac Research Center and Center for Heart Failure Research Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-6641","authenticated-orcid":false,"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital  Oslo Norway"},{"name":"University of Oslo  Oslo Norway"},{"name":"K.G.Jebsen Cardiac Research Center and Center for Heart Failure Research Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaspar","family":"Broch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital  Oslo Norway"},{"name":"K.G.Jebsen Cardiac Research Center and Center for Heart Failure Research Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"CD012264","article-title":"Exercise\u2010based cardiac rehabilitation in heart transplant recipients","volume":"4","author":"Anderson L","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91002-L"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199507000-00005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/RSMSMJ.51.3.6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2011.03.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.07.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v3.i4.78"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13143"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200010000-00015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-43773-6_14"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq158"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.1161"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9394060"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.103366"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.1.45"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401038"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60865-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027497"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.823"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12301"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004519"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.08.083"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.12.023"},{"key":"e_1_2_9_28_1","first-page":"5","article-title":"Nutritional anaemias: Report of a WHO scientific group","volume":"405","author":"WHO Scientific Group on Nutritional Anaemias & World Health Organization","year":"1968","journal-title":"World Health Organ Tech Rep Ser"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00272-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1154"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038516"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.01.1390"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.03.004"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:49:54Z","timestamp":1693280994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/ctr.14346"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14346","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"assertion":[{"value":"2021-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14346"}}