{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:05Z","timestamp":1790810885410,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:00:00Z","timestamp":1625961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Signal\u2010regulatory protein \u03b1 (SIRP\u03b1), a polymorphic inhibitory membrane\u2010bound receptor, and its ligand CD47 have recently been implicated in the modulation of innate immune allorecognition in murine models.<\/jats:p><jats:p>Here, we investigate the potential impact of SIRP\u03b1 donor\u2010recipient mismatches on graft outcomes in human kidney transplantation. To eliminate the specific role of HLA\u2010matching in alloresponse, we genotyped the two most common variants of SIRP\u03b1 in a cohort of 55 HLA\u2010identical, biologically\u2010related, donor\u2010recipient pairs. 69% of pairs were SIRP\u03b1 identical. No significant differences were found between donor\u2010recipient SIRP\u03b1\u2010mismatch status and T cell\u2010mediated rejection\/borderline changes (25.8%\u00a0vs. 25%) or slow graft function (15.8%\u00a0vs. 17.6%). A trend towards more graft failure (GF) (23.5%\u00a0vs. 5.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06), interstitial inflammation (50%\u00a0vs. 23%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06) and significant changes in peritubular capillaritis (<jats:italic>ptc<\/jats:italic>) (25%\u00a0vs. 0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) were observed in the SIRP\u03b1\u2010mismatched group. Unexpectedly, graft\u2010versus\u2010host (GVH) SIRP\u03b1\u2010mismatched pairs exhibited higher rates of GF and tubulitis (38%\u00a0vs. 5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.031 and .61 \u00b1 .88\u00a0vs. 0, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.019; respectively).<\/jats:p><jats:p>Whether the higher prevalence of <jats:italic>ptc<\/jats:italic> in SIRP\u03b1\u2010mismatched recipients and the higher rates of GF in GVH SIRP\u03b1\u2010mismatched pairs represent a potential role for SIRP\u03b1 in linking innate immunity and alloimmune rejection requires further investigation in larger cohorts.<\/jats:p>","DOI":"10.1111\/ctr.14406","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T08:10:56Z","timestamp":1624867856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of SIRP\u03b1 polymorphism on transplant outcomes in HLA\u2010identical living donor kidney transplantation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3521-6955","authenticated-orcid":false,"given":"Cynthia","family":"Garcia\u2010Sanchez","sequence":"first","affiliation":[{"name":"Transplant Immunology Laboratory Comprehensive Transplant Center Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Aurora","family":"Casillas\u2010Abundis","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Comprehensive Transplant Center Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Pinelli","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Comprehensive Transplant Center Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat R.","family":"Tambur","sequence":"additional","affiliation":[{"name":"Transplant Immunology Laboratory Comprehensive Transplant Center Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reut","family":"Hod\u2010Dvorai","sequence":"additional","affiliation":[{"name":"Pathology Department SUNY Upstate Medical University  Syracuse New York 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