{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:59:35Z","timestamp":1777517975278,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Total pancreatectomy with autologous islet transplant (TPAIT) is indicated for patients with chronic pancreatitis to improve quality of life while reducing complications from hypoglycemia. Continuous glucose monitoring (CGM) was used to assess overall islet function and the incidence of hypoglycemia pre\u2010 and post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen patients who underwent TPAIT at a single center from 2018 to 2020 were included. Pre\u2010operatively, patients were defined by diabetic status. HbA1c, stimulated C\u2010peptide, and CGM were used to characterize glycemic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre\u2010operatively, three patients had diabetes, and 16 patients did not have diabetes. Eight out of 16 non\u2010diabetic patients were insulin independent (50%). Of six non\u2010diabetic patients with\u00a0&gt;\u00a010% hypoglycemia on pre\u2010operative CGM, 33% were insulin\u2010independent post\u2010operatively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.3). Of non\u2010diabetic patients with \u2265 80% time in the euglycemic range, 62% were insulin\u2010independent post\u2010operatively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.2). For patients without diabetes, the median percent time in hypoglycemic range was reduced from 8% to 1% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Delta C\u2010peptide had a positive correlation with islet yield (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Conventional evaluation of TPAIT patients assesses primarily beta cell function. As pancreatogenic diabetes is concerning principally for the risk of hypoglycemia, assessment of alpha cell function can improve the quality of care. CGM better captures islet function and increases the identification of hypoglycemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14450","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T16:48:31Z","timestamp":1628268511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Use of Continuous Glucose Monitoring for evaluation of hypoglycemia pre\u2010 and post\u2010operatively for patients undergoing Total Pancreatectomy with Autologous Islet Cell Transplant"],"prefix":"10.1111","volume":"35","author":[{"given":"Jennifer S.","family":"Vonderau","sequence":"first","affiliation":[{"name":"Division of Abdominal Transplant Department of Surgery, University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittney M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant Department of Surgery, University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"DeCherney","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"McKnight","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Hanson","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant Department of Surgery, University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harlan","family":"Hanson","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant Department of Surgery, University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-0973","authenticated-orcid":false,"given":"Chirag S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant Department of Surgery, University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61852-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2007.08.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(00)80013-X"},{"key":"e_1_2_9_5_1","article-title":"Novel technique of total pancreatectomy before autologous islet transplants in chronic pancreatitis patients","author":"Desai CS","journal-title":"J Am Coll Surg"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1095-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.10.010"},{"key":"e_1_2_9_8_1","article-title":"Total pancreatectomy (TP) and islet autotransplantation (IAT) for chronic pancreatitis (CP)","author":"Sutherland DER","journal-title":"J Am Coll Surg"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000920"},{"key":"e_1_2_9_10_1","volume-title":"Collaborative islet transplant registry tenth annual report","author":"CITR Coordinating Center","year":"2017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JP9.0000000000000048"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.02.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2013.10.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0265-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13647"},{"key":"e_1_2_9_16_1","unstructured":"Mayo Clinic Laboratories. 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