{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:33:17Z","timestamp":1772112797669,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adults with congenital heart disease (ACHD) may undergo heart transplantation (HTx) despite increased risk of poor short\u2010term outcomes due to factors including surgical complexity and antibody sensitization. We assessed the clinical characteristics and outcomes of patients with ACHD in the current era referred for HTx at a single high\u2010volume transplant center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2010 to 2020, 37 ACHD patients were evaluated for HTx. ACHD HTx recipients were compared to non\u2010ACHD HTx recipients matched for age, sex, listing status, and prior cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 37 patients with ACHD, eight (21.6%) were declined for HTx. Of 29 ACHD patients listed, 19 (65.5%) underwent HTx. Compared with non\u2010ACHD HTx controls, the ACHD HTx recipients had more treated cellular (21.1%\u00a0vs. 15.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010) and antibody\u2010mediated (15.8%\u00a0vs. 10.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.033) rejection. There was no difference in hospital readmission or allograft vasculopathy at 1\u00a0year. There was a nonsignificant higher 1\u2010year mortality in ACHD HTx recipients (21.1%\u00a0vs. 7.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At a high\u2010volume transplant center, ACHD patients undergoing HTx appear to have a marginally higher risk of rejection, but no significant increase in 1\u2010year mortality. With careful selection and management, HTx for patients with ACHD may be feasible in the current era.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14451","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T19:39:51Z","timestamp":1628451591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Advanced heart failure and heart transplantation in adult congenital heart disease in the current era"],"prefix":"10.1111","volume":"35","author":[{"given":"Angelo L.","family":"de la Rosa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahli","family":"Singer\u2010Englar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California 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