{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:26:19Z","timestamp":1781655979622,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>We aimed to determine outcomes with transplanting kidneys from deceased donors with severe acute kidney injury requiring acute renal replacement therapy (RRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 172 recipients received a kidney from donors with acute kidney injury stage 3 (AKIN3) requiring RRT. We compared the study group to 528 recipients who received a kidney from donors with AKIN stage 3 not on RRT and 463 recipients who received\u00a0&lt;\u00a085% Kidney Donor Profile Index (KDPI) AKIN stage 0 kidney.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group donors were younger compared to the 2 control groups. Despite higher DGF in the study group, the length of hospital stay and acute rejection were similar. Death censored graft survival (96% AKIN3\u2010RRT vs. 97%AKIN3 no RRT vs. 96% KDPI\u00a0&lt;\u00a085% AKIN0,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.26) and patient survival with functioning graft at 1 year (95% across all groups,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.402) were similar. The estimated glomerular filtration rate were similar across the 3 groups after first month. Interstitial fibrosis and tubular atrophy score\u00a0\u2265\u00a02 on protocol biopsy at time 0, 4 and 12 months were similar. Primary nonfunction was rare and associated with high KDPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transplanting selected kidneys from deceased donors with AKIN3 requiring RRT is safe and has good outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14465","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:38:33Z","timestamp":1631493513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Successful outcomes with transplanting kidneys from deceased donors with acute kidney injuryon temporary renal replacement therapy"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-4452","authenticated-orcid":false,"given":"Pooja","family":"Budhiraja","sequence":"first","affiliation":[{"name":"Division of Nephrology Mayo Clinic Hospital Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond L.","family":"Heilman","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic Hospital Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-9519","authenticated-orcid":false,"given":"Caroline C.","family":"Jadlowiec","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan A.","family":"Khamash","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic Hospital Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Kodali","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic Hospital Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adyr A.","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-2014","authenticated-orcid":false,"given":"Amit K.","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunam S.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic Phoenix Arizona 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