{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:27:15Z","timestamp":1776140835132,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenovirus (AdV) is a serious infection following hematopoietic cell transplantation (HCT). Little is known about AdV viral kinetics and optimal threshold for initiation of pre\u2010emptive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010center retrospective study of 16 consecutive adult HCT recipients with detectable AdV identified over a 5\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median time to AdV reactivation after HCT was 176 days (IQR 86\u2013408). Nine patients received cidofovir, although 14\/16 had no tissue\u2010invasive disease. Among treated patients, median duration of viremia was shorter when initiating treatment at viral loads\u00a0&lt;\u00a010,000 copies\/ml (28\u00a0vs. 52 days). All\u2010cause mortality in this cohort was 44%. All six patients (five of which were untreated) with peak viral loads\u00a0&lt;\u00a010,000 copies\/ml survived; whereas only 30% (3\/10) of patients with peak viral loads greater than this threshold survived, despite most (<jats:italic>n<\/jats:italic>\u00a0=\u00a08; 80%) of them receiving cidofovir (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.01). Three\u2010month survival following diagnosis of AdV viremia was significantly lower with peak viremia\u00a0&gt;\u00a010,000 copies\/ml (100\u00a0vs. 17%; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AdV is associated with high all\u2010cause mortality, especially for viremia\u00a0&gt;\u00a010,000 copies\/ml. Delaying therapy until viremia reaches AdV levels \u226510,000 copies\/ml was associated with more protracted infection and poor outcomes. Larger studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14481","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T13:22:17Z","timestamp":1631539337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Viral kinetics and outcomes of adenovirus viremia following allogeneic hematopoietic cell transplantation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-6109","authenticated-orcid":false,"given":"Aditya","family":"Chandorkar","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and International Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-582X","authenticated-orcid":false,"given":"Anthony D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Sylvester Comprehensive Cancer Center  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele I.","family":"Morris","sequence":"additional","affiliation":[{"name":"Immunocompromised Host Service Division of Infectious Diseases University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Natori","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Sylvester Comprehensive Cancer Center  Miami Florida USA"},{"name":"Division of Infectious Diseases Miami Transplant Institute Jackson Health System  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Cellular Therapy Sylvester Comprehensive Cancer Center  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna 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