{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:30:36Z","timestamp":1790767836417,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney transplantation (KT) from hepatitis C virus infected (HCV+) donors to HCV negative recipients achieve excellent graft function but have relatively higher rates of post\u2010KT co\u2010infections presumably due to prolonged HCV viremia in\u00a0transmission\u2010and\u2010treat approach. Ezetimibe acts as an antagonist of Niemann\u2010Pick C1\u2010Like 1 receptor\u00a0required for HCV entry and theoretically can reduce HCV viremia. However,\u00a0no data is available to examine the role of ezetimibe as a bridge therapy between KT surgery and direct acting antiviral (DAA) initiation. A retrospective cohort study including 70 HCV+ to HCV negative KT recipients from Methodist University Hospital and Vanderbilt University Medical Center was performed to determine the association between ezetimibe usage and HCV viremia. Twenty patients received ezetimibe daily while 50 patients did not. Primary outcome of study was\u00a0mean HCV RNA level at 1\u20132\u00a0weeks post\u2010KT and before initiation of DAA. Median (IQR) viral load (VL) in log copies\/ml was one log lower in ezetimibe group versus\u00a0non\u2010ezetimibe group (4.1 [3.7\u20135.3] vs. 5.1 [4.4\u20135.5], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), and highest VL was also lower in ezetimibe group (4.2 [3.7\u20135.4] vs. 5.4 [4.7\u20135.9], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). We concluded that ezetimibe bridge therapy might be associated with reduction in HCV VL while waiting for DAA initiation in HCV+ to HCV negative KT recipients.<\/jats:p>","DOI":"10.1111\/ctr.14485","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T11:33:55Z","timestamp":1631705635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between ezetimibe usage and hepatitis C RNA levels in uninfected kidney transplant recipients who received hepatitis C infected kidneys"],"prefix":"10.1111","volume":"35","author":[{"given":"Ambreen","family":"Azhar","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Binari","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology and Hypertension Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Joglekar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tsujita","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute Methodist University Hospital  Memphis Tennessee USA"},{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Talwar","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute Methodist University Hospital  Memphis Tennessee USA"},{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanthi","family":"Balaraman","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute Methodist University Hospital  Memphis Tennessee USA"},{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshul","family":"Bhalla","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute Methodist University Hospital  Memphis Tennessee USA"},{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Eason","sequence":"additional","affiliation":[{"name":"James D. Eason Transplant Institute Methodist University Hospital  Memphis Tennessee USA"},{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-8450","authenticated-orcid":false,"given":"Isaac E.","family":"Hall","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Department of Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0003-8047","authenticated-orcid":false,"given":"George","family":"Rofaiel","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel C.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Kidney and Pancreas Transplantation Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Kidney and Pancreas Transplantation Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice P.","family":"Concepcion","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology and Hypertension Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-330X","authenticated-orcid":false,"given":"Miklos Z.","family":"Molnar","sequence":"additional","affiliation":[{"name":"Division of Nephrology &amp; Hypertension Department of Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019050462"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15530"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01405"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15054"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1705221"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2871"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15664"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.10.017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12882"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.06.012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006232"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15583"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i33.4481"},{"issue":"5","key":"e_1_2_10_15_1","first-page":"803","article-title":"Effect of ezetimibe in HCV viral load after liver transplantation","volume":"15","author":"Monrroy\u2010Bravo H","year":"2016","journal-title":"Ann Hepatol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2581"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02848.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30081-9"},{"key":"e_1_2_10_19_1","unstructured":"Romero\u2010MarreroC Combination therapy prevents HCV infection in non\u2010viremic organ recipients. 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