{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:29:01Z","timestamp":1788557341558,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients undergoing kidney transplantation traditionally receive liberal amounts of fluid during surgery. However, excessive fluids can lead to fluid overload and ileus. In this retrospective cohort study, we compared the effect of restrictive versus liberal fluid therapy on kidney transplantation outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent deceased\u2010donor kidney transplantation at Mayo Clinic from January 2014 to March 2019 were included. Those who received &lt;3 L of intravenous fluids intraoperatively were categorized as \u201crestrictive;\u201d those who received \u22653 L were categorized as \u201cliberal.\u201d The primary outcome was incidence of delayed graft function (DGF). Secondary outcomes included length of stay, readmission within 30 days, time to return of bowel function, and incidence of postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1171 patients included, 557 were in the restrictive group and 614 in the liberal group. The mean (SD) fluid intake was 2.17 (.54)\u00a0L in the restrictive group and 3.67 (.68)\u00a0L in the liberal group (<jats:italic>P<\/jats:italic>&lt;.001). There was no difference in DGF (relative risk, 1.03; <jats:italic>P<\/jats:italic>\u00a0= .56), length of stay (<jats:italic>P<\/jats:italic>\u00a0= .34), readmission (<jats:italic>P<\/jats:italic>\u00a0= .80), return of bowel function (<jats:italic>P<\/jats:italic>\u00a0= .71), or other postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative restrictive fluid therapy during kidney transplantation was not associated with DGF or worse outcomes when compared with liberal fluid therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14489","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T14:18:50Z","timestamp":1632233930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intraoperative fluid management and kidney transplantation outcomes: A retrospective cohort study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4210-0942","authenticated-orcid":false,"given":"Monica W.","family":"Harbell","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly B.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skye A.","family":"Bucker\u2010Petty","sequence":"additional","affiliation":[{"name":"Clinical Trials and Biostatistics Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-9594","authenticated-orcid":false,"given":"Jack W.","family":"Harbell","sequence":"additional","affiliation":[{"name":"Division of Transplant and Hepatobiliary Surgery Mayo Clinic  Scottsdale Arizona USA"},{"name":"Transplant Center Mayo Clinic Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510110079036"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V9112135"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14557"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198310000-00021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198210000-00008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2013.09.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2006.00356.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181d82ca8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491558"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2008.04.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn667"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/163757"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4952"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_9_16_1","unstructured":"R Core Team.R: A language and environment for statistical computing. 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