{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:49:03Z","timestamp":1780667343677,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bronchiolitis obliterans (BO) is a severe complication of Castleman disease (CD), a rare lymphoproliferative disease with unclear pathogenesis. Currently, there are no reports on the safety or outcomes of bilateral lung transplantation in patients with BO due to CD. This study aimed to characterize the clinical manifestations and features of BO and CD. We retrospectively analyzed the medical records of six consecutive patients with BO and CD who underwent bilateral lung transplantation between December 2012 and December 2020. The average age of patients at lung transplantation was 33 \u00b1 15 years, and the age range of patients at diagnosis of CD was about 9\u201356 years. The body mass index was 15.2 \u00b1 1.9\u00a0kg\/m<jats:sup>2<\/jats:sup>. The average time from diagnosis to lung transplantation was 4.1 \u00b1 2.7 years. All the patients had unicentric CD (UCD); five had concomitant paraneoplastic pemphigus, and four received extracorporeal membrane oxygenation during surgery. The average hospital stay was 51 \u00b1 53 days. Infection was the most common postoperative complication. CD did not recur in any of the patients. Thus, bilateral lung transplantation is a viable and safe treatment for selected patients with CD and BO, which can improve the quality of life and prolong survival.<\/jats:p>","DOI":"10.1111\/ctr.14496","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T07:47:34Z","timestamp":1632988054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bilateral lung transplantation for Castleman disease with end\u2010stage bronchiolitis obliterans"],"prefix":"10.1111","volume":"36","author":[{"given":"Bingqing","family":"Yue","sequence":"first","affiliation":[{"name":"Wuxi Lung Transplant Center Department of Thoracic Surgery Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Wuxi Lung Transplant Center Department of Thoracic Surgery Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Lung Transplantation Center of Lung Transplantation Center of Respiratory Diseases China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Wuxi Lung Transplant Center Department of Thoracic Surgery Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wei","sequence":"additional","affiliation":[{"name":"Wuxi Lung Transplant Center Department of Thoracic Surgery Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuxi Lung Transplant Center Department of Thoracic Surgery Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Lung Transplantation Center of Lung Transplantation Center of Respiratory Diseases China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-3801","authenticated-orcid":false,"given":"Jingyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuxi Lung Transplant Center Department of Thoracic Surgery Wuxi People's Hospital affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13378"},{"key":"e_1_2_9_3_1","first-page":"396\u2010400","article-title":"Case records of the Massachusetts general hospital; weekly clinicopathological exercises; founded by Richard C. 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