{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:25:37Z","timestamp":1784071537960,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Yerdel classification is widely used for describing the severity of portal vein thrombosis (PVT) in liver transplant (LT) candidates, but might not accurately predict transplant outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data regarding 97 adult patients with PVT who underwent LT, investigating whether the complexity of portal reconstruction could better correlate with transplant outcome than the site and extent of the thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>79\/97 (80%) patients underwent thrombectomy and anatomical anastomosis (TAA), 18\/97 (20%) patients underwent non\u2010anatomical physiological reconstructions (non\u2010TAA). PVT Yerdel grade was 1\u20132 in 72\/97 (74%) patients, and 3\u20134 in 25\/97 (26%) patients. Univariate analysis revealed higher 30\u2010day mortality, 90\u2010day mortality, 1\u2010year mortality, and a higher rate of severe early complications in the non\u2010TAA group than in the TAA group (<jats:italic>p<\/jats:italic> = .018, .001, .014, .009, respectively). In the model adjusted for PVT Yerdel grade, non\u2010TAA remained independently associated with higher 30\u2010day, 90\u2010day, and 1\u2010year mortality (<jats:italic>p<\/jats:italic> = .021, .007, and .015, respectively). The portal vein re\u2010thrombosis and overall patient and graft survival rates were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In our experience, the complexity of portal reconstruction better correlated with transplant outcome than the Yerdel classification, which did not even appear to be a reliable predictor of the surgical complexity and technique.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14501","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T09:39:58Z","timestamp":1633945198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Liver transplantation in patients with non\u2010neoplastic portal vein thrombosis: 20 years of experience in a single center"],"prefix":"10.1111","volume":"36","author":[{"given":"Domenico","family":"Pinelli","sequence":"first","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3037-7904","authenticated-orcid":false,"given":"Stefania","family":"Camagni","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Amaduzzi","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Frosio","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fontanella","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Carioli","sequence":"additional","affiliation":[{"name":"FROM Research Foundation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Guizzetti","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Fabrizio","family":"Zambelli","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Giovanelli","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII  Bergamo 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