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This study aimed to evaluate the feasibility and efficacy of a modified conditioning regimen in haploidentical HSCT (haplo\u2010HSCT) for severe\u2010cardiotoxic\u2010risk SAA patients. This BuCy\n                    <jats:sup>low<\/jats:sup>\n                    Flu conditioning utilized busulfan (Bu, 3.2\u00a0mg\/kg for 2 days), low\u2010dose Cy (100\u00a0mg\/kg), fludarabine (150\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), and rabbit antithymocyte globulin (rATG, 10\u00a0mg\/kg). Compared to BuCy conditioning using high\u2010dose Cy of 200\u00a0mg\/kg, Bu of 3.2\u00a0mg\/kg for 2 days, and rATG of 10\u00a0mg\/kg, the incidence of severe cardiotoxicity of BuCy\n                    <jats:sup>low<\/jats:sup>\n                    Flu conditioning was significantly decreased (2.17%\u00a0vs 12.80%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.032). The engraftment rates (100% for neutrophil and 84.44% for platelet) were favorable. The probabilities of 100\u2010day transplant\u2010related mortality were similar in the BuCy\n                    <jats:sup>low<\/jats:sup>\n                    Flu and the BuCy group (8.75%\u00a0vs 10.53%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.671). Both 1\u2010year overall survival (88.79%\u00a0vs 84.66%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.357) and 1\u2010year failure\u2010free survival (84.78%\u00a0vs 81.70%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.535) were comparable. The BuCy\n                    <jats:sup>low<\/jats:sup>\n                    Flu group had higher rates of cytomegalovirus and Epstein\u2013Barr virus reactivation. In conclusion, the BuCy\n                    <jats:sup>low<\/jats:sup>\n                    Flu provided reduced severe cardiotoxicity, and achieved favorable engraftment and survival. Our results suggest BuCy\n                    <jats:sup>low<\/jats:sup>\n                    Flu conditioning can be a feasible alternative for haplo\u2010HSCT recipients at risk of severe cardiotoxicity.\n                  <\/jats:p>","DOI":"10.1111\/ctr.14514","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T14:59:32Z","timestamp":1634741972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A modified conditioning regimen based on low\u2010dose cyclophosphamide and fludarabine for haploidentical hematopoietic stem cell transplant in severe aplastic anemia patients at risk of severe cardiotoxicity"],"prefix":"10.1111","volume":"36","author":[{"given":"Fan","family":"Lin","sequence":"first","affiliation":[{"name":"Peking University Institute of Hematology Peking University People's Hospital National Clinical Research Centre for Hematologic Disease Beijing Key Laboratory of Haematopoietic Stem Cell Transplant  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Institute of Hematology Peking University People's Hospital National Clinical Research Centre for Hematologic Disease Beijing Key Laboratory of Haematopoietic Stem Cell Transplant  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University Institute of Hematology Peking University People's Hospital National Clinical Research Centre for Hematologic Disease Beijing Key Laboratory of Haematopoietic Stem Cell Transplant  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Peking University Institute of Hematology Peking University People's Hospital National Clinical Research 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