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Pre\u2010operative PVT was associated with increased overall mortality (HR 1.45, 95% CI 1.27\u20131.65) and graft loss (HR 1.58, 95% CI 1.34\u20131.85). In particular, grade 3 (HR 1.59, 95% CI 1.00\u20132.51) and 4 (HR 2.24, 95% CI 1.45\u20133.45) PVT significantly increased mortality, but not grade 1 or 2 PVT. Patients with PVT receiving living donor (HR 1.54, 95% CI 1.24\u20131.91) and deceased donor (HR 1.52, 95% CI 1.21\u20131.92) liver transplantation had increased mortality, with no significant difference between transplant types (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.13). Furthermore, pre\u2010transplant PVT was associated with higher occurrence of post\u2010transplant PVT (OR 5.06, 95% CI 3.89\u20136.57). Waitlist mortality was not significantly increased in patients with pre\u2010transplant PVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Graft failure, mortality, and post\u2010operative PVT are more common in pre\u2010transplant PVT patients, especially in grade 3 or 4 PVT. Prophylactic anticoagulation can be considered to reduce re\u2010thrombosis and improve survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14520","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T18:23:59Z","timestamp":1635013439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Meta\u2010analysis and systematic review: Prevalence, graft failure, mortality, and post\u2010operative thrombosis in liver transplant recipients with pre\u2010operative portal vein thrombosis"],"prefix":"10.1111","volume":"36","author":[{"given":"Jun Wei","family":"Yeo","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Shi Ni","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Faculty of Science National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Chun Liang","family":"Lim","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-1569","authenticated-orcid":false,"given":"Cheng Han","family":"Ng","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren Jun Hao","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe Wen Lin","family":"Tay","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Syn","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Biostatistics &amp; Modelling Domain Saw Swee Hock School of Public Health National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Yu","family":"Tham","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-5061","authenticated-orcid":false,"given":"Daniel Q.","family":"Huang","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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