{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:32:36Z","timestamp":1790865156413,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited data on the predictors and outcomes of new or worsening respiratory failure among lung transplant (LT) patients with Coronavirus disease 2019 (COVID\u201019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all the LT patients diagnosed with COVID\u201019 during a 1\u2010year period (March 2020 to February 2021; <jats:italic>n<\/jats:italic>\u00a0=\u00a054; median age: 60, 20\u201373 years; M:F 37:17). Development of new or worsening respiratory failure (ARF) was the primary outcome variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence of ARF was 48.1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a026). More than 20% of patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) needed intubation and mechanical ventilation. Body mass index\u00a0&gt;\u00a025 Kg\/m<jats:sup>2<\/jats:sup> (adjusted OR: 5.7, .99\u201332.93; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05) and peak D\u2010dimer levels\u00a0&gt;\u00a0.95 mcg\/ml (adjusted OR: 24.99, 1.77\u2013353.8; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017) were independently associated with ARF while anticoagulation use prior to COVID\u201019 was protective (adjusted OR: .024, .001\u2013.55; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Majority patients survived the acute illness (85.2%). Pre\u2010infection chronic lung allograft dysfunction (CLAD) was an independent predictor of mortality (adjusted HR: 5.03, 1.14\u201322.25; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>COVID\u201019 is associated with significant morbidity and mortality among LT patients. Patients on chronic anticoagulation seem to enjoy favorable outcomes, while higher BMI and peak D\u2010dimer levels are associated with development of ARF. Pre\u2010infection CLAD is associated with an increased risk of death from COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14540","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T11:30:32Z","timestamp":1637235032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors and outcomes of respiratory failure among lung transplant patients with COVID\u201019"],"prefix":"10.1111","volume":"36","author":[{"given":"Adrian","family":"Lawrence","sequence":"first","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke D.","family":"Mahan","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish R.","family":"Mohanka","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Bollineni","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-6077","authenticated-orcid":false,"given":"Vaidehi","family":"Kaza","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo M.","family":"La Hoz","sequence":"additional","affiliation":[{"name":"Infectious Disease and Geographic Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Population and Data Sciences University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey D.","family":"Kershaw","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance S.","family":"Terada","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Torres","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-1537","authenticated-orcid":false,"given":"Amit","family":"Banga","sequence":"additional","affiliation":[{"name":"Divisions of Pulmonary and Critical Care Medicine  Dallas Texas 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