{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:03:19Z","timestamp":1787238199781,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In acute decompensated heart failure (ADHF), noninvasive markers that predict morbidity and mortality are limited. Liver stiffness measurement (LSM) increases with hepatic fibrosis; however, it may be falsely elevated in patients with ADHF in the absence of liver disease. We investigated whether elevated LSM predicts cardiac outcomes in ADHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective study, we examined 52 ADHF patients without liver disease between 2016 and 2017. Patients underwent liver 2D shear wave elastography (SWE) and were followed for 12 months to assess the outcomes of left ventricular assist device (LVAD), heart transplant (HT) or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median LSM was elevated in patients who received an LVAD or HT within 30\u2010days compared to those who did not (median [IQR]: 55.6 [22.5 \u2013 63.4] vs 13.8 [9.5 \u2013 40.3] kPa,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.049). Moreover, the risk of composite outcome was highest in the 3rd tertile (&gt;\u00a039.8\u00a0kPa compared to 1\n                      <jats:sup>st<\/jats:sup>\n                      and 2\n                      <jats:sup>nd<\/jats:sup>\n                      combined, HR 2.83, 95% CI 1.20\u2010 6.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02). Each 1\u2010kPa increase in LSM was associated with a 1%\u2010increase in the incidence rate of readmissions (IRR 1.01, 95% CI 1.00\u20101.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LSM may serve as a novel noninvasive tool to determine LVAD, HT, or death in patients with ADHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.14545","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T03:58:45Z","timestamp":1637812725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Liver stiffness and prediction of cardiac outcomes in patients with acute decompensated heart failure"],"prefix":"10.1111","volume":"36","author":[{"given":"Nishah","family":"Panchani","sequence":"first","affiliation":[{"name":"Tinsley Harrison Internal Medicine Residency Program The University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7703-0123","authenticated-orcid":false,"given":"Philipp","family":"Schulz","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Baylor Scott &amp; White Research Institute Baylor University Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-9214","authenticated-orcid":false,"given":"Johanna","family":"Van Zyl","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor University Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-8755","authenticated-orcid":false,"given":"Joost","family":"Felius","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor University Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Baxter","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor University Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Taek","family":"Yoon","sequence":"additional","affiliation":[{"name":"Texas A&amp;M College of Medicine  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harith","family":"Baldawi","sequence":"additional","affiliation":[{"name":"Texas A&amp;M College of Medicine  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarinder","family":"Bindra","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor University Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-5670","authenticated-orcid":false,"given":"Sumeet K","family":"Asrani","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor University Medical Center  Dallas Texas 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