{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:47:10Z","timestamp":1793767630951,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multicenter, prospective, observational study to compare the relative bioavailability of once\u2010daily tacrolimus formulations in de novo kidney transplant recipients. De novo kidney transplant recipients who started a tacrolimus\u2010based regimen were included 14\u00a0days post\u2010transplant and followed up for 6 months. Data from 218 participants were evaluated: 129 in the LCPT group (Envarsus) and 89 in the PR\u2010Tac (Advagraf) group. Patients in the LCPT group exhibited higher relative bioavailability (C<jats:sub>min<\/jats:sub> \/total daily dose [TDD]) vs. PR\u2010Tac (61% increase; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) with similar C<jats:sub>min<\/jats:sub> and 30% lower TDD levels (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). The incidence of treatment failure was 3.9% in the LCPT group and 9.0% in the PR\u2010Tac group (<jats:italic>P<\/jats:italic> = .117). Study discontinuation rates were 6.2% in the LCPT group and 12.4% in the PR\u2010Tac group (<jats:italic>P<\/jats:italic> = .113). Adverse events, renal function and other complications were comparable between groups. The median accumulated dose of tacrolimus in the LCPT group from day 14 to month 6 was 889 mg. Compared to PR\u2010Tac, LCPT showed higher relative bioavailability, similar effectiveness at preventing allograft rejection, comparable effect on renal function, safety, adherence, treatment failure and premature discontinuation rates.<\/jats:p>","DOI":"10.1111\/ctr.14550","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T14:43:32Z","timestamp":1638369812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bioavailability of once\u2010daily tacrolimus formulations used in clinical practice in the management of <i>De Novo<\/i> kidney transplant recipients: the better study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2801-6752","authenticated-orcid":false,"given":"Constantino","family":"Fernandez Rivera","sequence":"first","affiliation":[{"name":"Nephrology Department University Hospital A Coru\u00f1a  A Coru\u00f1a 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