{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:19:07Z","timestamp":1780564747541,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010HL130272"],"award-info":[{"award-number":["R01\u2010HL130272"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with short telomere\u2010related interstitial lung disease (ILD) have worse outcomes after lung transplantation. We hypothesized that post\u2010transplant airway complications, including dehiscence and bronchial stenosis, would be more common in the short telomere ILD lung transplant population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multi\u2010institutional (Brigham and Women's Hospital, Groupe de Transplantation de la SPLF) retrospective cohort study of 63 recipients between 2009 and 2019 with ILD and short telomeres, compared to 4359 recipients from the Scientific Registry of Transplant Recipients with ILD and no known telomeropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the short telomere cohort, six recipients (9.5%) developed dehiscence and nine recipients (14.3%) developed stenosis, compared to 60 (1.4%) and 149 (3.4%) in the control, respectively. After adjusting for age, sex, and bilaterality, the presence of short telomeres was associated with higher odds of dehiscence (odds ratio (OR)\u00a0=\u00a08.24, 95% confidence interval (CI)\u00a0=\u00a03.34 20.29, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and stenosis (OR\u00a0=\u00a04.63, 95% CI 2.21 9.69, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The association between the presence of short telomeres and post\u2010transplant dehiscence and stenosis suggest that airway complications may be a contributor to increased morbidity and mortality in patients with telomere\u2010related ILD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14552","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T18:06:16Z","timestamp":1638381976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Airway complications in lung transplant recipients with telomere\u2010related interstitial lung disease"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-9639","authenticated-orcid":false,"given":"Bina","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Messika","sequence":"additional","affiliation":[{"name":"Physiopathology and Epidemiology of Respiratory Diseases UMR1152 INSERM and Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Courtwright","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Fran\u00e7ois","family":"Mornex","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Universit\u00e9 Lyon 1  INRAE, EPHE, IVPC Lyon France"},{"name":"Hospices Civils de Lyon  Lyon France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Pulmonaires Rares  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Hirschi","sequence":"additional","affiliation":[{"name":"Service de Pneumologie Centre de comp\u00e9tence des maladies pulmonaires rares H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Roux","sequence":"additional","affiliation":[{"name":"Service de Pneumologie H\u00f4pital Foch  UVSQ France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Le Pavec","sequence":"additional","affiliation":[{"name":"Service de chirurgie thoracique et de transplantation pulmonaire Centre Chirurgical 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Pneumologie Centre de comp\u00e9tences des maladies pulmonaires rares CHU Nord AP\u2010HM Marseille Aix\u2010 Marseille Universit\u00e9 IHU M\u00e9diterran\u00e9e Infection MEPHI  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie Le","family":"Borgne","sequence":"additional","affiliation":[{"name":"Service de Pneumologie Centre de comp\u00e9tence des maladies pulmonaires rares H\u00f4pital Larrey CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde Phillips","family":"Houlbracq","sequence":"additional","affiliation":[{"name":"Physiopathology and Epidemiology of Respiratory Diseases UMR1152 INSERM and Universit\u00e9 de Paris  Paris France"},{"name":"H\u00f4pital Bichat\u2010Claude Bernard Service de Pneumologie et Transplantation Pulmonaire APHP.Nord\u2010Universit\u00e9 de Paris  Paris 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