{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:55:22Z","timestamp":1791345322634,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870512"],"award-info":[{"award-number":["81870512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical efficacy and safety of iguratimod (IGU) for reducing panel reactive antibody (PRA) in high\u2010mismatched renal transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible recipients positive for PRAs who received or did not receive IGU treatment were enrolled. We retrospectively reviewed, collected, and analyzed statistically the clinical data of the recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 80 recipients were included for further analysis. After IGU was administered for 9\u00a0months, no significant difference was found in the change rates of donor specific antibodies between two groups. Meanwhile, the reduction in the PRAs in the IGU group was greater than that in the non\u2010IGU group in anti\u2010human leukocyte antigen (HLA) class I and class II, anti\u2010HLA class I, anti\u2010HLA class II, anti\u2010HLA A, and anti\u2010HLA DR antibodies. However, no differences were found in the anti\u2010HLA B, anti\u2010HLA Cw, anti\u2010HLA DP, and anti\u2010HLA DQ antibodies between the two groups. No serious adverse events were reported, and the incidence of adverse events was comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PRA levels in high\u2010mismatched renal transplant recipients were significantly reduced after the administration of IGU. The high safety of IGU was also determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14565","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T10:22:56Z","timestamp":1640082176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Iguratimod reduces panel reactive antibody in high mismatched renal transplant recipients: One single\u2010center experience"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-7324","authenticated-orcid":false,"given":"Dengyuan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Urology the First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu P. R. 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