{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:29:44Z","timestamp":1762432184376,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluated the outcomes of combined heart\u2010kidney transplantation in the United States using hepatitis C positive (HCV+) donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults undergoing combined heart\u2010kidney transplantation from 2015 to 2020 were identified in the United Network for Organ Sharing registry. Patients were stratified by donor HCV status. Kaplan\u2010Meier curves with multivariable Cox regression models were used for risk\u2010adjustment in a propensity\u2010matched cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 950 patients underwent heart\u2010kidney transplantation of which 7.8% (n\u00a0=\u00a075) used HCV+ donors; 68% (n\u00a0=\u00a051) were viremic and 32% (n\u00a0=\u00a024) were non\u2010viremic donors. Unadjusted 1\u2010year recipient survival was similar between HCV+ versus HCV\u2010 donors (84%\u00a0vs 88%, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.33). Risk\u2010adjusted analysis in the propensity\u2010matched cohort showed HCV+ donor use did not confer increased risk of 1\u2010year mortality (hazard ratio .63, 95% CI .17\u20102.32; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.49). Sub\u2010group analysis showed viremic and non\u2010viremic HCV+ donors had similar 1\u2010year survival as well (84%\u00a0vs 84%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with recipients of HCV\u2010 donor dual heart\u2010kidney transplants, recipients of HCV+ organs had comparable 1\u2010year survival and clinical outcomes after combined transplantation. Although future studies should evaluate other outcomes related to HCV+ donor use, this practice appears safe and should be expanded further in the heart\u2010kidney transplant population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14581","type":"journal-article","created":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T13:57:55Z","timestamp":1641131875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["National trends and outcomes of heart\u2010kidney transplantation using hepatitis C positive donors"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-2833","authenticated-orcid":false,"given":"Carlos E.","family":"Diaz\u2010Castrillon","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren V.","family":"Huckaby","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Witer","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas H.","family":"Pope","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc R.","family":"Katz","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhakar K.","family":"Baliga","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-8345","authenticated-orcid":false,"given":"Arman","family":"Kilic","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Division of Cardiothoracic Surgery Medical University of South Carolina  Charleston South Carolina 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