{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:16:46Z","timestamp":1790439406727,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Serum phosphatidylethanol (PEth) is a highly sensitive test to detect alcohol use. We evaluated whether the availability of PEth testing impacted rates of liver transplant evaluation terminations and delistings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical record data were collected for patients who initiated transplant evaluation due to alcohol\u2010related liver disease in the pre\u2010PEth (2017) or PEth (2019) eras. Inverse probability weighting (IPW) was used to balance baseline patient characteristics. Outcomes included termination of evaluation or delisting due to alcohol use; patients were censored at receipt of transplant; death was considered a competing risk. The Fine\u2010Gray method was performed to determine whether PEth testing affected risk of evaluation termination\/ delisting due to alcohol use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and seventy\u2010five patients with alcohol\u2010related indications for transplant (157 in 2017; 210 in 2019) were included. The final IPW\u2010adjusted model for the composite outcome of terminations\/delisting due to alcohol use retained two significant variables (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05): PEth era and BMI category. Patients evaluated during the PEth era were almost three times more likely to experience an alcohol\u2010related termination\/delisting than those in the pre\u2010PEth era (sHR\u00a0=\u00a02.86; 95%CI 1.67\u20134.97)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that availability of PEth testing at our institution was associated with a higher rate of exclusion of patients from eligibility for liver transplant. Use of PEth testing has significant potential to inform decisions regarding transplant candidacy for patients with alcohol\u2010related liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14595","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T15:09:31Z","timestamp":1642518571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Availability of PEth testing is associated with reduced eligibility for liver transplant among patients with alcohol\u2010related liver disease"],"prefix":"10.1111","volume":"36","author":[{"given":"Ranya","family":"Selim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology\u00a0and Hepatology Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueren","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loralee B.","family":"Rupp","sequence":"additional","affiliation":[{"name":"Center for Health Policy and Health Services Research Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri","family":"Trudeau","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Naffouj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Shamaa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelwahab","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed\u2010Mohammed","family":"Jafri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\u00a0and Hepatology Henry Ford Health System  Detroit Michigan USA"},{"name":"Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart C.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\u00a0and Hepatology Henry Ford Health System  Detroit Michigan USA"},{"name":"Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antu","family":"Segal","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Transplant Institute Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-1846","authenticated-orcid":false,"given":"Humberto C.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\u00a0and Hepatology Henry Ford Health System  Detroit Michigan USA"},{"name":"Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"756","article-title":"Cirrhosis and chronic liver failure: part I. 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