{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:43:40Z","timestamp":1774007020921,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For primary sclerosing cholangitis (PSC) patients undergoing liver transplantation (LT), a consensus regarding biliary reconstruction remains unresolved. Choledochoduodenostomy (CDD) represents an alternative to Roux\u2010en\u2010Y (RY) and duct\u2010to\u2010duct. We compared long\u2010term post\u2010transplant outcomes between CDD and RY.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of patients transplanted for PSC who received CDD or RY, with minimum 12\u2010months follow\u2010up. The primary outcome was need for biliary intervention, with either percutaneous transhepatic cholangiography (PTC) or endoscopic retrograde cholangiopancreatography (ERCP). Secondary outcomes included biliary stricture(s) and cholangitis admission(s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010three patients were transplanted between August 2004 and October 2019 (34 living donor [LDLT] and 59 deceased donor [DDLT]; 40 RY, 53 CDD). Need for either ERCP or PTC was similar (45.0% RY vs. 32.1% CDD, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.203), though RY exhibited more anastomotic strictures (AS) (35.0% RY vs. 11.3% CDD, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), which was also observed in LDLT subanalyses (50.0% LDLT\/RY vs. 10.0% LDLT\/CDD; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.036). Cholangitis admissions were more frequent in RY versus CDD (37.5%\u00a0vs. 15.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CDD does not impart greater risk of biliary complications, and RY may have an incremental effect combined with LDLT status for predisposing to AS. CDD maintains standard endoscopic access without additional risk of biliary complications, thus should be considered when anatomically feasible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14597","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T11:54:22Z","timestamp":1642593262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Choledochoduodenostomy is associated with fewer post\u2010transplant biliary complications compared to Roux\u2010en\u2010Y in primary sclerosing cholangitis patients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-0520","authenticated-orcid":false,"given":"Emily R.","family":"Jonica","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"James R.","family":"Burton","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Pomposelli","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","article-title":"Biliary reconstruction in liver transplant patients with primary sclerosing cholangitis, duct\u2010to\u2010duct or Roux\u2010en\u2010Y?","volume":"31","author":"Shamsaeefer A","year":"2017","journal-title":"Clin Transplant"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23827"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000113807.74942.D2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01371.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12513"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9885-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01173.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21313"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.232"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.10.035"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","unstructured":"EsfehJM EghtesadB HodgkinsonP et\u00a0al.Duct\u2010to\u2010duct biliary reconstruction in patients with primary sclerosing cholangitis undergoing liver transplantation.HPB (Oxford).2011;13(9):651\u2010655.","DOI":"10.1111\/j.1477-2574.2011.00346.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.01.066"},{"issue":"10","key":"e_1_2_8_14_1","first-page":"e5837","article-title":"Is it really SUMP syndrome? A case report","volume":"11","author":"Suliman MS","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_8_15_1","unstructured":"SchreuderAM FrankenLC vanDierenS BesselinkMG BuschOR vanGulikTM Choleddochoduodenostomy versus hepaticojejunostomy \u2013 a matched case\u2010control analysis.HPB (Oxford).2020."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477335"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2017.0082"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2004.00254.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24872"},{"issue":"5","key":"e_1_2_8_20_1","first-page":"316","article-title":"Management of biliary strictures after liver transplantation","volume":"11","author":"Villa NA","year":"2015","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21764"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T20:49:34Z","timestamp":1692996574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,27]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/ctr.14597"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14597","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,27]]},"assertion":[{"value":"2021-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14597"}}