{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:01Z","timestamp":1753878601609,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The literature lacks data on World Health Organization (WHO) class II and III deficient liver donors who underwent right hepatectomy during living donor liver transplantation (LDLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, we compared the perioperative outcomes of 15 glucose\u20106 phosphate dehydrogenase (G6PD) deficient living liver donors with a matched cohort of 39 nondeficient living liver donors undergoing right lobe donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 15 G6PD deficient donors, four (26.67%) donors had class II, and 11 (73.34%) had class III G6PD deficiency. The mean postoperative trough hemoglobin level was significantly lower in the deficient group than the nondeficient group (9.38\u00a0\u00b1\u00a01.59\u00a0g\/dL vs. 10.27 \u00b1 .91\u00a0g\/dL, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.046). The mean peak indirect bilirubin level was significantly higher in the deficient group than the nondeficient group (2.22\u00a0\u00b1 1.38\u00a0mg\/dL vs. 1.40 \u00b1 .89\u00a0mg\/dL, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.047), and a similar trend was observed in total serum bilirubin (3.99\u00a0\u00b1 2.57\u00a0mg\/dL vs. 2.99\u00a0\u00b1 1.46\u00a0mg\/dL, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.038). Biochemical evidence of hemolysis was found only in three (20%) deficient donors, but none of them needed a blood transfusion. No mortality was observed in either group. All other parameters, including demographics, operative parameters, graft characteristics, and hospital stay were comparable between both groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>G6PD deficiency with WHO class II and above should not be considered a contraindication for right lobe donation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14627","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T18:28:26Z","timestamp":1647196106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety of glucose\u20106 phosphate dehydrogenase deficient donors in living right lobe liver donation"],"prefix":"10.1111","volume":"36","author":[{"given":"Abdul Wahab","family":"Dogar","sequence":"first","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7819-6910","authenticated-orcid":false,"given":"Kaleem","family":"Ullah","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Ghaffar","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shams\u2010","family":"Ud\u2010din","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh 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Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Raza","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munaza","family":"Zafar","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Asif","family":"Baig","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Affan","family":"Qaiser","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmat Ullah","family":"Shahwani","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary Unit Pir Abdul Qadir Shah Jelani Institute of Medical Sciences  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Liver Transplant and Hepatobiliary, Max Super Speciality Hospital Saket (Max Saket)  New Delhi 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