{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:32:27Z","timestamp":1792171947501,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There has been a shift over decades in the diagnostic indications for lung transplantation in children; in particular, there has been a reduction in the proportion of pediatric cystic fibrosis (CF) patients undergoing lung transplantation early in life, and more transplants occurring in other diagnostic groups. Here, we examine trends in pediatric lung transplantation with regards to indications by analyzing data from the United Network of Organ Sharing, the International Society for Heart and Lung Transplantation Thoracic Transplant Registry, and other sources. Over the past two years, there has been a precipitous decline in both the number of transplants due to CF and the proportion of CF cases relative to the total number of transplants, likely not solely due to the COVID\u201019 pandemic. In 2020, primary pulmonary arterial hypertension for the first\u2010time surpassed CF as main indication for pediatric lung transplantation in the United States, a finding that is also reflected in international data. We discuss the effect of novel CFTR modulator therapies as a major factor leading to this shifting landscape. Based on our trending, pulmonary hypertension\u2010related diagnoses and pediatric interstitial lung diseases are rising indications, for which we suggest adjustments of consensus guidelines around candidate selection criteria.<\/jats:p>","DOI":"10.1111\/ctr.14634","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T12:23:50Z","timestamp":1646396630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The changing landscape of pediatric lung transplantation"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7108-3785","authenticated-orcid":false,"given":"Nicholas","family":"Avdimiretz","sequence":"first","affiliation":[{"name":"Division of Pediatric Respiratory Medicine Stollery Children Hospital University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-5646","authenticated-orcid":false,"given":"Christian","family":"Benden","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.63710120001010"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2002.00217.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.003"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.07.018"},{"key":"e_1_2_14_6_1","volume-title":"OPTN Database","year":"2021"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2013-002790"},{"key":"e_1_2_14_8_1","volume-title":"CF Foundation Research Milestones","year":"2019"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003522"},{"key":"e_1_2_14_10_1","volume-title":"Canadian Blood Services 2020 System Progress Data \u2013 Organ and Tissue Donation and Transplantation","year":"2020"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14210"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1715436"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.06.002"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14129"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84800-925-7_18"},{"issue":"8","key":"e_1_2_14_16_1","first-page":"1024","article-title":"Pediatric lung transplantation: indications and outcomes","volume":"6","author":"Kirkby S","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043900"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.11.903"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05304"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.4187\/aarc0427"},{"key":"e_1_2_14_21_1","unstructured":"Cystic Fibrosis Foundation Patient Registry 2019 Annual Data Report. 2020. 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