{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:51:36Z","timestamp":1759402296141,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiac involvement may occur in many forms of muscular dystrophy (MD). While cardiac disease may progress to warrant heart transplantation (HTx), there may be contraindications related to extra\u2010cardiac disease including pulmonary and skeletal muscle involvement that limit overall survival and impairs post\u2010transplant rehabilitation efforts. This study describes the MD HTx experience at a single high\u2010volume center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the clinical characteristics and outcomes of patients with MD with heart failure (HF) (<jats:italic>n<\/jats:italic>\u00a0=\u00a028), patients with MD status post HTx (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and non\u2010MD HTx control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) matched 2:1 for age at transplant, sex, listing status, and antibody sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with MD who underwent HTx had increased ventilator days (2\u00a0vs. 1 days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.013), increased hospital length of stay (20\u00a0vs. 12 days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022), and increased discharge to inpatient rehab (60%\u00a0vs. 8%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). By 1 year post HTx, patients with MD more often required assistive devices for walking (55%\u00a0vs. 10%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Nonetheless, post\u2010HTx survival was similar at 1 year (100%\u00a0vs. 97.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.48) and 5 years (95.0%\u00a0vs. 87.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.36). Of the HTx recipients with MD, 95% were followed by a neurologist, 60% by a neuromuscular specialist as part of the Muscular Dystrophy Association Clinic at our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transplantation is a feasible option for patients with MD and advanced HF. MD patients who undergo transplantation may benefit from multidisciplinary specialized care to optimize MD\u2010related morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14645","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T06:33:09Z","timestamp":1647412389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Heart transplantation in muscular dystrophy: Single\u2010center analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-7401","authenticated-orcid":false,"given":"Parth","family":"Visrodia","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil J","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Burford","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Cardiology Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jignesh K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon A.","family":"Kobashigawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Kittleson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07815-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000526"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.08.030"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005447"},{"issue":"5","key":"e_1_2_8_6_1","first-page":"804","article-title":"Heart transplantation in patients with muscular dystrophy associated with end\u2010stage cardiomyopathy","volume":"12","author":"Rees W","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2017.01024"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.09.039"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.02.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.02.027"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001416"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000892"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.081"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:34:12Z","timestamp":1692819252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,21]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/ctr.14645"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14645","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2022,3,21]]},"assertion":[{"value":"2022-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14645"}}