{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:52:44Z","timestamp":1785912764099,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malnutrition is a known risk factor for postoperative morbidity and mortality in patients awaiting liver transplantation (LT). Malnutrition is a potentially reversible risk factor, though there are no clear guidelines on the best mechanism for an improvement. It also remains unclear if preoperative nutritional interventions have benefits to post\u2010transplant outcomes for transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Primary objective: To identify if preoperative optimization of nutritional status is associated with improved short\u2010term outcomes after LT. Secondary Objectives: To determine if preoperative improvement of malnutrition improves short\u2010term outcomes after LT, as well as if weight loss in obese patients affects short\u2010term outcomes after LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data sources<\/jats:title><jats:p>Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. POSPERO Protocol ID: CRD42021237450<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3851 records were identified in searching the databases, 3843 records were excluded by not fulfilling eligibility criteria. Seven full\u2010text articles were included for the final analysis of which three were randomized controlled trials, one was prospective observational studies, and three were retrospective observational studies. No appreciable difference in mortality, post\u2010transplant complication rate was noted across the studies. Length of stay (LOS) was noted to be shorter in two observational studies of Vitamin D deficiency in liver transplant patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have made a weak recommendation supporting pre\u2010transplant nutritional supplementation due to possible benefit in reducing LOS as well as the lack of harm (Quality of Evidence low | Grade of Recommendation; Weak). No effective conclusions were reached for the secondary objectives due to the conflicting evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14647","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T17:19:56Z","timestamp":1647623996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The role of preoperative optimization of the nutritional status on the improvement of short\u2010term outcomes after liver transplantation? A review of the literature and expert panel recommendations"],"prefix":"10.1111","volume":"36","author":[{"suffix":"III","given":"David W.","family":"Victor","sequence":"first","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zanetto","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit\/Gastroenterology Department of Surgery, Oncology, and Gastroenterology Padova University Hospital  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo J.","family":"Montano\u2010Loza","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Liver Unit University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"Heimbach","sequence":"additional","affiliation":[{"name":"Division of 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