{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:01:28Z","timestamp":1779246088395,"version":"3.51.4"},"reference-count":86,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few data are available on discharge criteria after living liver donation (LLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the features for fit for discharge checklist after LLD to prevent unnecessary re\u2010hospitalizations and to provide international expert recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data sources<\/jats:title><jats:p>Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. The critical outcomes included were complications rates and liver function (defined by elevated bilirubin and INR) (CRD42021260725).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 57\/1710 studies were included in qualitative analysis and 28\/57 on the final analysis. No randomized controlled trials were identified. The complications rate was reported in 20\/28 studies and ranged from 7.8% to 71.2%. Post hepatectomy liver function was reported in 13 studies. The Quality of Evidence (QoE) was Low and Very\u2010Low for complications rate and liver function test, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Monitoring and prevention of donor complications\u00a0should be crucial in decision making of discharge.\u00a0Pain and diet\u00a0control, removal of all drains and catheters, deep venous thrombosis prophylaxis, and use\u00a0routine imaging (CT scan or liver ultrasound) before discharge should be included as fit for discharge checklist <jats:italic>(QoE; Low | GRADE of recommendation; Strong)<\/jats:italic>. Transient Impaired liver function (defined by elevated bilirubin and INR), a prognostic marker of outcome after liver resection,\u00a0usually occurs after donor right hepatectomy and should be monitored.\u00a0Improving trends for\u00a0bilirubin and INR value should be observed by day\u00a05\u00a0post hepatectomy\u00a0and be included in the\u00a0fit for discharge checklist. (<jats:italic>QoE; Very\u2010Low | GRADE; Strong)<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14677","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T21:53:41Z","timestamp":1650146021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["When is it safe for the liver donor to be discharged home and prevent unnecessary re\u2010hospitalizations? \u2013 A systematic review of the literature and expert panel recommendations"],"prefix":"10.1111","volume":"36","author":[{"given":"Alessandra","family":"Mazzola","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Liver transplant unit Pit\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris 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