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In heart transplant recipients, angiotensin\u2010converting enzyme inhibitors have been demonstrated to be a keystone for the treatment of hypertension with a wide spectrum of pleiotropic molecular effects ranging from improvement of the peripheral vascular system to regulation of the fluid and sodium balance. In addition, angiotensin\u2010converting enzyme inhibitors may be also useful in the prevention of graft failure, cardiac allograft vasculopathy (CAV) and chronic kidney disease (CKD) progression. Further tailored multicenter and randomized studies are warranted to confirm the pleiotropic clinical effects of ACEi therapy in HTRs and to support more extended use in daily clinical practice. Finally in the near future, the use of novel pharmacological agents that inhibit the renin\u2010angiotensin\u2010aldosterone system (RAAS) such as the neprilysin inhibitor sacubitril should be investigated in heart transplant recipients.<\/jats:p>","DOI":"10.1111\/ctr.14696","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T01:40:02Z","timestamp":1651887602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin\u2010converting enzyme inhibitor therapy after heart transplant: From molecular basis to clinical effects"],"prefix":"10.1111","volume":"36","author":[{"given":"Daniele","family":"Masarone","sequence":"first","affiliation":[{"name":"Heart Failure Unit Department of Cardiology AORN dei Colli\u2010Monaldi Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan 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